What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol

Ole Vang; Nihal Ahmad; Clifton A. Baile; Joseph A. Baur; Karen Brown; Anna Csiszar; Dipak K. Das; Dominique Delmas; Carmem Gottfried; Hung-Yun Lin; Qing-Yong Ma; Partha Mukhopadhyay; Namasivayam Nalini; John M. Pezzuto; Tristan Richard; Yogeshwer Shukla; Young-Joon Surh; Thomas Szekeres; Thomas Szkudelski; Thomas Walle; Joseph M. Wu

doi:10.1371/journal.pone.0019881

What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol

Ole Vang, Nihal Ahmad, Clifton A. Baile, Joseph A. Baur, Karen Brown, Anna Csiszar, Dipak K. Das, Dominique Delmas, Carmem Gottfried, Hung-Yun Lin, Qing-Yong Ma, Partha Mukhopadhyay, Namasivayam Nalini, John M. Pezzuto, Tristan Richard, Yogeshwer Shukla, Young-Joon Surh, Thomas Szekeres, Thomas Szkudelski, Thomas WalleJoseph M. Wu

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Background: Resveratrol is a natural compound suggested to have beneficial health effects. However, people are
consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore,
scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data
are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in
Helsingør, Denmark.
Methodology: Literature search in databases as PubMed and ISI Web of Science in combination with manual search was
used to answer the following five questions: 1Can resveratrol be recommended in the prevention or treatment of human
diseases?; 2Are there observed ‘‘side effects’’ caused by the intake of resveratrol in humans?; 3What is the relevant dose of
resveratrol?; 4What valid data are available regarding an effect in various species of experimental animals?; 5Which relevant
(overall) mechanisms of action of resveratrol have been documented?
Conclusions/Significance: The overall conclusion is that the published evidence is not sufficiently strong to justify a
recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary
sources. On the other hand, animal data are promising in prevention of various cancer types, coronary heart diseases and
diabetes which strongly indicate the need for human clinical trials. Finally, we suggest directions for future research in
resveratrol regarding its mechanism of action and its safety and toxicology in human subjects.

Original language	English
Journal	P L o S One
Volume	6
Issue number	6
Number of pages	11
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0019881
Publication status	Published - 2011

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Cite this

Vang, O., Ahmad, N., Baile, C. A., Baur, J. A., Brown, K., Csiszar, A., Das, D. K., Delmas, D., Gottfried, C., Lin, H.-Y., Ma, Q.-Y., Mukhopadhyay, P., Nalini, N., Pezzuto, J. M., Richard, T., Shukla, Y., Surh, Y.-J., Szekeres, T., Szkudelski, T., ... Wu, J. M. (2011). What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol. P L o S One, 6(6). https://doi.org/10.1371/journal.pone.0019881

@article{7031a3e845344b7ca0332baa64fc4993,

title = "What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol",

abstract = "Background: Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsing{\o}r, Denmark. Methodology: Literature search in databases as PubMed and ISI Web of Science in combination with manual search was used to answer the following five questions: 1Can resveratrol be recommended in the prevention or treatment of human diseases?; 2Are there observed {\textquoteleft}{\textquoteleft}side effects{\textquoteright}{\textquoteright} caused by the intake of resveratrol in humans?; 3What is the relevant dose of resveratrol?; 4What valid data are available regarding an effect in various species of experimental animals?; 5Which relevant (overall) mechanisms of action of resveratrol have been documented? Conclusions/Significance: The overall conclusion is that the published evidence is not sufficiently strong to justify a recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary sources. On the other hand, animal data are promising in prevention of various cancer types, coronary heart diseases and diabetes which strongly indicate the need for human clinical trials. Finally, we suggest directions for future research in resveratrol regarding its mechanism of action and its safety and toxicology in human subjects.",

keywords = "Resveratrol",

author = "Ole Vang and Nihal Ahmad and Baile, {Clifton A.} and Baur, {Joseph A.} and Karen Brown and Anna Csiszar and Das, {Dipak K.} and Dominique Delmas and Carmem Gottfried and Hung-Yun Lin and Qing-Yong Ma and Partha Mukhopadhyay and Namasivayam Nalini and Pezzuto, {John M.} and Tristan Richard and Yogeshwer Shukla and Young-Joon Surh and Thomas Szekeres and Thomas Szkudelski and Thomas Walle and Wu, {Joseph M.}",

year = "2011",

doi = "10.1371/journal.pone.0019881",

language = "English",

volume = "6",

journal = "P L o S One",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "6",

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Vang, O, Ahmad, N, Baile, CA, Baur, JA, Brown, K, Csiszar, A, Das, DK, Delmas, D, Gottfried, C, Lin, H-Y, Ma, Q-Y, Mukhopadhyay, P, Nalini, N, Pezzuto, JM, Richard, T, Shukla, Y, Surh, Y-J, Szekeres, T, Szkudelski, T, Walle, T & Wu, JM 2011, 'What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol', P L o S One, vol. 6, no. 6. https://doi.org/10.1371/journal.pone.0019881

TY - JOUR

T1 - What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol

AU - Vang, Ole

AU - Ahmad, Nihal

AU - Baile, Clifton A.

AU - Baur, Joseph A.

AU - Brown, Karen

AU - Csiszar, Anna

AU - Das, Dipak K.

AU - Delmas, Dominique

AU - Gottfried, Carmem

AU - Lin, Hung-Yun

AU - Ma, Qing-Yong

AU - Mukhopadhyay, Partha

AU - Nalini, Namasivayam

AU - Pezzuto, John M.

AU - Richard, Tristan

AU - Shukla, Yogeshwer

AU - Surh, Young-Joon

AU - Szekeres, Thomas

AU - Szkudelski, Thomas

AU - Walle, Thomas

AU - Wu, Joseph M.

PY - 2011

Y1 - 2011

N2 - Background: Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark. Methodology: Literature search in databases as PubMed and ISI Web of Science in combination with manual search was used to answer the following five questions: 1Can resveratrol be recommended in the prevention or treatment of human diseases?; 2Are there observed ‘‘side effects’’ caused by the intake of resveratrol in humans?; 3What is the relevant dose of resveratrol?; 4What valid data are available regarding an effect in various species of experimental animals?; 5Which relevant (overall) mechanisms of action of resveratrol have been documented? Conclusions/Significance: The overall conclusion is that the published evidence is not sufficiently strong to justify a recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary sources. On the other hand, animal data are promising in prevention of various cancer types, coronary heart diseases and diabetes which strongly indicate the need for human clinical trials. Finally, we suggest directions for future research in resveratrol regarding its mechanism of action and its safety and toxicology in human subjects.

AB - Background: Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark. Methodology: Literature search in databases as PubMed and ISI Web of Science in combination with manual search was used to answer the following five questions: 1Can resveratrol be recommended in the prevention or treatment of human diseases?; 2Are there observed ‘‘side effects’’ caused by the intake of resveratrol in humans?; 3What is the relevant dose of resveratrol?; 4What valid data are available regarding an effect in various species of experimental animals?; 5Which relevant (overall) mechanisms of action of resveratrol have been documented? Conclusions/Significance: The overall conclusion is that the published evidence is not sufficiently strong to justify a recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary sources. On the other hand, animal data are promising in prevention of various cancer types, coronary heart diseases and diabetes which strongly indicate the need for human clinical trials. Finally, we suggest directions for future research in resveratrol regarding its mechanism of action and its safety and toxicology in human subjects.

KW - Resveratrol

U2 - 10.1371/journal.pone.0019881

DO - 10.1371/journal.pone.0019881

M3 - Journal article

SN - 1932-6203

VL - 6

JO - P L o S One

JF - P L o S One

IS - 6

ER -