Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo-beta-lactamase-1 (NDM-1)

Kurt Fuursted, Lone Vedel Schøler, Frank Hansen, Karen Dam, Martin Saxtorph Bojer, Anette Hammerum, Frederik Dagnæs-Hansen, Anders Olsen, Yousef Jasemian, Carsten Struve

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    The aim of the study was to compare and evaluate virulence in five strains of Klebsiella pneumoniae, including an isolate carrying New Delhi metallo-beta-lactamase-1 (NDM-1). In vivo virulence was assessed using a murine sepsis model and using the nematode Caenorhabditis elegans killing model, and in vitro virulence by assessing various virulence factors. The NDM-1 carrying K. pneumoniae isolate was the most virulent in the murine sepsis model but there was no clear cut correlation to in vitro virulence factors or killing in C. elegans. It is concluded that K. pneumoniae carrying NDM-1 have an intrinsic virulence potential, which in coexistence with its multiresistance could promote and partly explain its epidemiological success.
    Original languageEnglish
    JournalMicrobes and Infection
    Issue number2
    Pages (from-to)155-158
    Publication statusPublished - Feb 2012


    • Klebsiella pneumoniae
    • New Delhi metallo-beta-lactamase-1
    • Virulence
    • Animal study
    • Caenorhabditis elegans

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