Type 2 diabetes models

Dorte Xenia Gram

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    Abstract

    This chapter deals with type 2 diabetes in vivo models and techniques suitable for testing new anti-diabetic compounds. In particular, the testing of TRP antagonist for beneficial effects against type 2 diabetes is considered. There are many choices of both in vitro techniques and in vivo models and in principle they can be combined in various ways. The comprehensive listing of all relevant tests and models is too long to be discussed and described in detail here. Therefore, a few selected in vivo experiments (author's models of choice) are described. These are acute experiments after single dose of the TRP antagonist in rodents and could/should be repeated after chronic dosing. Non-rodent models are briefly discussed, and a single model and test are suggested but not described in detail. The experiments are aiming at demonstrating that the TRP antagonists are effective in treating hyperglycemia, impaired glucose tolerance, impaired insulin secretion, and insulin resistance in vivo and should, thus, be sufficient to demonstrate preclinical proof of concept of a TRP antagonist in type 2 diabetes in rodents. The experiments are suggestions and could be replaced or supplemented by others.
    Original languageEnglish
    Title of host publicationMethods in Pharmacology and Toxicology
    EditorsA. Szallasi, T. Biro
    Volume2012
    Place of PublicationNew York
    PublisherSpringer
    Publication date2012
    Pages319-332
    ISBN (Print)978-162703094-6
    DOIs
    Publication statusPublished - 2012
    SeriesMethods in Pharmacology and Toxicology
    ISSN1557-2153

    Cite this

    Gram, D. X. (2012). Type 2 diabetes models. In A. Szallasi, & T. Biro (Eds.), Methods in Pharmacology and Toxicology (Vol. 2012, pp. 319-332). New York: Springer. Methods in Pharmacology and Toxicology https://doi.org/10.1007/978-1-62703-095-3_20
    Gram, Dorte Xenia. / Type 2 diabetes models. Methods in Pharmacology and Toxicology . editor / A. Szallasi ; T. Biro. Vol. 2012 New York : Springer, 2012. pp. 319-332 (Methods in Pharmacology and Toxicology).
    @inbook{4136aaa614554efc880a0b6ff7fc2b74,
    title = "Type 2 diabetes models",
    abstract = "This chapter deals with type 2 diabetes in vivo models and techniques suitable for testing new anti-diabetic compounds. In particular, the testing of TRP antagonist for beneficial effects against type 2 diabetes is considered. There are many choices of both in vitro techniques and in vivo models and in principle they can be combined in various ways. The comprehensive listing of all relevant tests and models is too long to be discussed and described in detail here. Therefore, a few selected in vivo experiments (author's models of choice) are described. These are acute experiments after single dose of the TRP antagonist in rodents and could/should be repeated after chronic dosing. Non-rodent models are briefly discussed, and a single model and test are suggested but not described in detail. The experiments are aiming at demonstrating that the TRP antagonists are effective in treating hyperglycemia, impaired glucose tolerance, impaired insulin secretion, and insulin resistance in vivo and should, thus, be sufficient to demonstrate preclinical proof of concept of a TRP antagonist in type 2 diabetes in rodents. The experiments are suggestions and could be replaced or supplemented by others.",
    author = "Gram, {Dorte Xenia}",
    year = "2012",
    doi = "10.1007/978-1-62703-095-3_20",
    language = "English",
    isbn = "978-162703094-6",
    volume = "2012",
    pages = "319--332",
    editor = "A. Szallasi and T. Biro",
    booktitle = "Methods in Pharmacology and Toxicology",
    publisher = "Springer",

    }

    Gram, DX 2012, Type 2 diabetes models. in A Szallasi & T Biro (eds), Methods in Pharmacology and Toxicology . vol. 2012, Springer, New York, Methods in Pharmacology and Toxicology, pp. 319-332. https://doi.org/10.1007/978-1-62703-095-3_20

    Type 2 diabetes models. / Gram, Dorte Xenia.

    Methods in Pharmacology and Toxicology . ed. / A. Szallasi; T. Biro. Vol. 2012 New York : Springer, 2012. p. 319-332 (Methods in Pharmacology and Toxicology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    TY - CHAP

    T1 - Type 2 diabetes models

    AU - Gram, Dorte Xenia

    PY - 2012

    Y1 - 2012

    N2 - This chapter deals with type 2 diabetes in vivo models and techniques suitable for testing new anti-diabetic compounds. In particular, the testing of TRP antagonist for beneficial effects against type 2 diabetes is considered. There are many choices of both in vitro techniques and in vivo models and in principle they can be combined in various ways. The comprehensive listing of all relevant tests and models is too long to be discussed and described in detail here. Therefore, a few selected in vivo experiments (author's models of choice) are described. These are acute experiments after single dose of the TRP antagonist in rodents and could/should be repeated after chronic dosing. Non-rodent models are briefly discussed, and a single model and test are suggested but not described in detail. The experiments are aiming at demonstrating that the TRP antagonists are effective in treating hyperglycemia, impaired glucose tolerance, impaired insulin secretion, and insulin resistance in vivo and should, thus, be sufficient to demonstrate preclinical proof of concept of a TRP antagonist in type 2 diabetes in rodents. The experiments are suggestions and could be replaced or supplemented by others.

    AB - This chapter deals with type 2 diabetes in vivo models and techniques suitable for testing new anti-diabetic compounds. In particular, the testing of TRP antagonist for beneficial effects against type 2 diabetes is considered. There are many choices of both in vitro techniques and in vivo models and in principle they can be combined in various ways. The comprehensive listing of all relevant tests and models is too long to be discussed and described in detail here. Therefore, a few selected in vivo experiments (author's models of choice) are described. These are acute experiments after single dose of the TRP antagonist in rodents and could/should be repeated after chronic dosing. Non-rodent models are briefly discussed, and a single model and test are suggested but not described in detail. The experiments are aiming at demonstrating that the TRP antagonists are effective in treating hyperglycemia, impaired glucose tolerance, impaired insulin secretion, and insulin resistance in vivo and should, thus, be sufficient to demonstrate preclinical proof of concept of a TRP antagonist in type 2 diabetes in rodents. The experiments are suggestions and could be replaced or supplemented by others.

    U2 - 10.1007/978-1-62703-095-3_20

    DO - 10.1007/978-1-62703-095-3_20

    M3 - Book chapter

    SN - 978-162703094-6

    VL - 2012

    SP - 319

    EP - 332

    BT - Methods in Pharmacology and Toxicology

    A2 - Szallasi, A.

    A2 - Biro, T.

    PB - Springer

    CY - New York

    ER -

    Gram DX. Type 2 diabetes models. In Szallasi A, Biro T, editors, Methods in Pharmacology and Toxicology . Vol. 2012. New York: Springer. 2012. p. 319-332. (Methods in Pharmacology and Toxicology). https://doi.org/10.1007/978-1-62703-095-3_20