Abstract
From the ethyl acetate extract of the stems of Miliusa velutina, seven compounds (1–7) were isolated, including two new compounds such as mivelutina A acid (1), mivelutina B acid (2) and one known compound mivelutina B methyl ester (3). For this NMR data were not known previously. Their relative structures were elucidated based on NMR spectroscopic analysis. The absolute configuartions were determined based on DFT calculations of 13C chemical shifts. All of the seven compounds were screened for their in vitro cytotoxic activities against HepG2 cell line using the SRB assay. Epoxyconiferyl alcohol (7) showed the highest potential for the cytotoxicity of cancer cell lines HepG2 with the IC50 values of 95.94 μg/mL (527 μM).
| Original language | English |
|---|---|
| Journal | Natural Product Research |
| Volume | 36 |
| Pages (from-to) | 553-559 |
| Number of pages | 7 |
| ISSN | 1478-6419 |
| DOIs | |
| Publication status | Published - 15 Jan 2022 |
Keywords
- Naturstof
- Biological screening
- cancer cells
- structure elucidation
- mivelutina
- HepG2
- Miliusa velutina
- sesquiterpene
- epoxyconiferyl alcohol
- sesquiterpenes
- DFT calculations
- absolute configuration
Link to document
Datasets
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Two new sesquiterpenes from the stems of Miliusa velutina
Van Nguyen Thien, T. (Creator), Vo, T. K. L. (Creator), Dang, P. H. (Creator), Ngoc Huynh, V. (Creator), Ngo, T. T. D. (Creator), Nguyen, T. M. (Creator), Hansen, P. E. (Creator) & That, Q. T. (Creator), figshare, 24 Aug 2020
DOI: 10.6084/m9.figshare.12849152.v1, https://doi.org/10.6084/m9.figshare.12849152.v1
Dataset