The use of rabbits in atherosclerosis research. Diet and drug intervention in different rabbit models exposed to selected dietary fats and the calcium antagonist (-)-anipamil: evaluation and comparison of rabbit models

Alicja Mortensen

    Research output: Book/ReportPh.D. thesisResearch

    Abstract

    Laboratory animal models play an important role in atherosclerosis research. One of the most popular laboratory animal species in this field of research is the rabbit. The rabbit fulfils most of the criteria for an animal model for human atherosclerosis. Three rabbit models were established and used for dietary or drug intervention: 1) the cholesterol-fed normolipidemic rabbit, 2) the 1% cholesterol- fed heterozygous Watanabe heritable hyperlipidemic (WHHL) rabbit and 3) the homozygous WHHL rabbit. The reproductive performance and physiological blood lipid levels in growing and adult heterozygous and homozygous WHHL and normolipidemic rabbit were characterized. The position of the rabbit models in atherosclerosis research was discussed. The characteristic features of cholesterolfed and WHHL rabbis were compared.
    Original languageEnglish
    PublisherNational Food Agency of Denmark
    Number of pages89
    ISBN (Print)87-601-6558-8
    Publication statusPublished - 1995

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