The role of CDX2 in intestinal homeostasis and inflammation

Mehmet Coskun*, Jesper Thorvald Troelsen, Ole Haagen Nielsen

*Corresponding author for this work

Research output: Contribution to journalReviewpeer-review

Abstract

Many transcription factors are known to control transcription at several promoters, while others are only active at a few places. However, due to their importance in controlling cellular functions, aberrant transcription factor function and inappropriate gene regulation have been shown to play a causal role in a large number of diseases and developmental disorders. Inflammatory bowel disease (IBD) is characterized by a chronically inflamed mucosa caused by dysregulation of the intestinal immune homeostasis. The aetiology of IBD is thought to be a combination of genetic and environmental factors, including luminal bacteria. The Caudal-related homeobox transcription factor 2 (CDX2) is critical in early intestinal differentiation and has been implicated as a master regulator of the intestinal homeostasis and permeability in adults. When expressed, CDX2 modulates a diverse set of processes including cell proliferation, differentiation, cell adhesion, migration, and tumorigenesis. In addition to these critical cellular processes, there is increasing evidence for linking CDX2 to intestinal inflammation. The aim of the present paper was to review the current knowledge of CDX2 in regulation of the intestinal homeostasis and further to reveal its potential role in inflammation.

Original languageEnglish
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1812
Issue number3
Pages (from-to)283-289
Number of pages7
ISSN0925-4439
DOIs
Publication statusPublished - Mar 2011
Externally publishedYes

Keywords

  • CDX2
  • IBD
  • Inflammation
  • Intestine
  • MAPK
  • NF-κB

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