The Population Genetics of Antibiotic Resistance

B. R.  Levin; M. Lipsitch; V. Perrot; S. Schrag; R. Antia; Lone Simonsen; N.  Moore Walker; F. M. Stewart

doi:10.1093/clinids/24.Supplement_1.S9

The Population Genetics of Antibiotic Resistance

B. R. Levin^*, M. Lipsitch, V. Perrot, S. Schrag, R. Antia, Lone Simonsen, N. Moore Walker, F. M. Stewart

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Mathematical models are used to ascertain the relationship between the incidence of antibiotic treatment and the frequency of resistant bacteria in the commensal flora of human hosts, as well as the rates at which these frequencies would decline following a cessation of antibiotic use. Recent studies of the population biology of plasmid-encoded and chromosomal antibiotic resistance are reviewed for estimates of the parameters of these models and to evaluate other factors contributing to the fate of antibiotic-resistant bacteria in human hosts. The implications of these theoretical and empirical results to the future of antibacterial chemotherapy are discussed.

Original language	English
Journal	Clinical Infectious Diseases
Volume	24
Issue number	1
Pages (from-to)	S9–S16
Number of pages	8
ISSN	1058-4838
DOIs	https://doi.org/10.1093/clinids/24.Supplement_1.S9
Publication status	Published - 1997
Externally published	Yes

Link to document

10.1093/clinids/24.Supplement_1.S9

Cite this

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title = "The Population Genetics of Antibiotic Resistance",

abstract = "Mathematical models are used to ascertain the relationship between the incidence of antibiotic treatment and the frequency of resistant bacteria in the commensal flora of human hosts, as well as the rates at which these frequencies would decline following a cessation of antibiotic use. Recent studies of the population biology of plasmid-encoded and chromosomal antibiotic resistance are reviewed for estimates of the parameters of these models and to evaluate other factors contributing to the fate of antibiotic-resistant bacteria in human hosts. The implications of these theoretical and empirical results to the future of antibacterial chemotherapy are discussed.",

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AU - Levin, B. R.

AU - Lipsitch, M.

AU - Perrot, V.

AU - Schrag, S.

AU - Antia, R.

AU - Simonsen, Lone

AU - Moore Walker, N.

AU - Stewart, F. M.

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AB - Mathematical models are used to ascertain the relationship between the incidence of antibiotic treatment and the frequency of resistant bacteria in the commensal flora of human hosts, as well as the rates at which these frequencies would decline following a cessation of antibiotic use. Recent studies of the population biology of plasmid-encoded and chromosomal antibiotic resistance are reviewed for estimates of the parameters of these models and to evaluate other factors contributing to the fate of antibiotic-resistant bacteria in human hosts. The implications of these theoretical and empirical results to the future of antibacterial chemotherapy are discussed.

U2 - 10.1093/clinids/24.Supplement_1.S9

DO - 10.1093/clinids/24.Supplement_1.S9

M3 - Journal article

SN - 1058-4838

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