Synthesis of macrocyclic lactams and lactones via ring-closing olefin metathesis

W. P. D. Goldring, A. S. Hodder, L. Weiler

Research output: Contribution to journalJournal articleResearchpeer-review


Lactones and lactams 4–6 were synthesized from a series of acyclic dienes 1–3 via ring-closing olefin metathesis, as shown in equation 1. The geometry of the resulting double bond was determined, and the EIZ ratios compared to values from molecular mechanics calculations.
Original languageEnglish
JournalTetrahedron Letters
Issue number28
Pages (from-to)4955-4958
Number of pages4
Publication statusPublished - 1998
Externally publishedYes

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