Residential exposure to PM2.5 components and risk of childhood non-hodgkin lymphoma in Denmark: A nationwide register-based case-control study

Ulla Arthur Hvidtfeldt*, Friederike Erdmann, Stine Kjaer Urhoj, Jørgen Brandt, Camilla Geels, Matthias Ketzel, Lise M. Frohn, Jesper Heile Christensen, Mette Sørensen, Ole Raaschou-Nielsen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

In a recent study, we observed an increased risk of childhood non-Hodgkin lymphoma (NHL) associated with exposure to fine atmospheric particulate matter (PM2.5) and black carbon (BC). In this nationwide register-based case-control study, we focus on specific components of PM2.5 in relation to childhood NHL in Denmark (1981–2013) by identifying all incidents of childhood NHL cases in the Danish Cancer Registry (n = 170) and four (cancer-free) randomly selected controls matched by date of birth and sex. We applied PM2.5 concentrations and the following sub-components: secondary organic aerosols (SOA), secondary inorganic aerosols (SIA; i.e., NO3 , NH4 + and SO4 2−), BC, organic carbon (OC) and sea salt. We calculated a time-weighted exposure average from birth to index-date at all addresses. Odds ratios (ORs) were adjusted for register-based socio-demographic variables. We observed adjusted ORs and 95% confidence intervals (95% CI) of 2.05 (1.10, 3.83) per interquartile range (IQR, 4.83 µg/m3) PM2.5 and 1.73 (0.68, 4.41) per IQR (3.71 µg/m3) SIA, 0.95 (0.71, 1.29) per IQR (0.05 µg/m3) SOA, 1.22 (1.02, 1.46) per IQR (0.39 µg/m3) BC, 1.02 (0.83, 1.26) per IQR (0.56 µg/m3) OC and 1.01 (0.79, 1.30) per IQR (0.87 µg/m3) sea salt, respectively. The estimates were attenuated after adjustment for PM2.5, whereas the OR for PM2.5 remained increased regardless of adjustment for specific components. The findings indicate that the previously observed relation between PM2.5 and childhood NHL may be related to BC (as reported in our previous study) but also partly to SIA, but the role of specific chemical components of PM2.5 remains ambiguous.

Original languageEnglish
Article number8949
JournalInternational Journal of Environmental Research and Public Health
Volume17
Issue number23
Pages (from-to)1-10
Number of pages10
ISSN1661-7827
DOIs
Publication statusPublished - 1 Dec 2020

Keywords

  • Carbonaceous particles
  • Childhood Non-Hodgkin Lymphoma
  • Particulate matter components
  • Register-based study
  • Secondary inorganic aerosols
  • Secondary organic aerosols

Cite this