Platinum(II) complexes block the entry of T4 phage DNA into the host cells

Gustaw Kerszman, Jens Josephsen, Bo Fernholm

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    The efficiency of multiplicity reactivation of T4 particles inactivated by platinum(II) complexes is very low. The same is true for marker rescue and functional survival of genes. This can be at least partly explained by the inability of most inactivated virus particles to introduce their DNA into the host cells as demonstrated by electron microscopy. Conformational changes in the DNA, formation of DNA-DNA and DNA-protein cross-links and the damage of proteins participating in the injection process could be responsible for the phenomenon observed.
    Original languageEnglish
    JournalChemico-Biological Interactions
    Volume28
    Issue number2-3
    Pages (from-to)259-268
    Number of pages10
    ISSN0009-2797
    DOIs
    Publication statusPublished - 1979

    Cite this

    Kerszman, Gustaw ; Josephsen, Jens ; Fernholm , Bo . / Platinum(II) complexes block the entry of T4 phage DNA into the host cells. In: Chemico-Biological Interactions. 1979 ; Vol. 28, No. 2-3. pp. 259-268.
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    abstract = "The efficiency of multiplicity reactivation of T4 particles inactivated by platinum(II) complexes is very low. The same is true for marker rescue and functional survival of genes. This can be at least partly explained by the inability of most inactivated virus particles to introduce their DNA into the host cells as demonstrated by electron microscopy. Conformational changes in the DNA, formation of DNA-DNA and DNA-protein cross-links and the damage of proteins participating in the injection process could be responsible for the phenomenon observed.",
    author = "Gustaw Kerszman and Jens Josephsen and Bo Fernholm",
    year = "1979",
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    Platinum(II) complexes block the entry of T4 phage DNA into the host cells. / Kerszman, Gustaw; Josephsen, Jens; Fernholm , Bo .

    In: Chemico-Biological Interactions, Vol. 28, No. 2-3, 1979, p. 259-268.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - Platinum(II) complexes block the entry of T4 phage DNA into the host cells

    AU - Kerszman, Gustaw

    AU - Josephsen, Jens

    AU - Fernholm , Bo

    PY - 1979

    Y1 - 1979

    N2 - The efficiency of multiplicity reactivation of T4 particles inactivated by platinum(II) complexes is very low. The same is true for marker rescue and functional survival of genes. This can be at least partly explained by the inability of most inactivated virus particles to introduce their DNA into the host cells as demonstrated by electron microscopy. Conformational changes in the DNA, formation of DNA-DNA and DNA-protein cross-links and the damage of proteins participating in the injection process could be responsible for the phenomenon observed.

    AB - The efficiency of multiplicity reactivation of T4 particles inactivated by platinum(II) complexes is very low. The same is true for marker rescue and functional survival of genes. This can be at least partly explained by the inability of most inactivated virus particles to introduce their DNA into the host cells as demonstrated by electron microscopy. Conformational changes in the DNA, formation of DNA-DNA and DNA-protein cross-links and the damage of proteins participating in the injection process could be responsible for the phenomenon observed.

    U2 - 10.1016/0009-2797(79)90166-2

    DO - 10.1016/0009-2797(79)90166-2

    M3 - Journal article

    VL - 28

    SP - 259

    EP - 268

    JO - Chemico-Biological Interactions

    JF - Chemico-Biological Interactions

    SN - 0009-2797

    IS - 2-3

    ER -