Picking up good vibrations: Exploration of the intensified vibratory mill via a modern design of experiments

Elene De Cleyn, René Holm, Tatsiana Khamiakova, Guy Van den Mooter*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

Abstract

The aim of this work was to strengthen the understanding of the intensified vibratory mill by unravelling the milling process in terms of the particle size reduction and heat generation via a modern design of experiments approach. Hence, the influence of five process parameters (acceleration, breaks during milling, bead size, milling time and bead-suspension ratio) was investigated via an I-optimal design. Particle size was measured via laser diffraction and the temperature of the sample after milling was computed. To advance our understanding, a mechanistic model for the set-up of wet-stirred media milling processes was applied on the observed milling trends. A generic approach for the optimisation of the milling process was retrieved and included the optimisation of the bead size and intermittent pausing for effective cooling. To finetune the remaining process parameters, the present work provides contour plots and strong predictive models. With these models, the particle size and the temperature after milling of suspensions manufactured with the intensified vibratory mill could be forecasted for the first time.

Original languageEnglish
Article number120367
JournalInternational Journal of Pharmaceutics
Volume598
ISSN0378-5173
DOIs
Publication statusPublished - 1 Apr 2021

Keywords

  • Design of Experiments
  • Intensified vibratory milling
  • Method optimisation
  • Milling
  • Particle size reduction
  • Quality by Design

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