Outbreak of vertigo in Wyoming: Possible role of an enterovirus infection

Lone Simonsen, A. S. Khan, H. E. Gary, C. Hanson, M. A. Pallansch, S. Music, Robert C. Holman, A. Stewart, D. D. Erdman, N. H. Arden, I. Kaufmann Arenberg, Lawrence B. Schonberger

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Abstract

An epidemiologic investigation was conducted to characterize and evaluate the possibility of a viral aetiology of an outbreak of acute vertigo in Hot Springs Country, Wyoming, during autumn 1992. Case-finding identified Hot Springs County residents who sought medical attention for new onset vertigo during 1 August, 1992–31 January 1993. Thirty-five case-patients and 61 matched controls were interviewed and serum specimens were obtained during January 1993. Case-patients were more likely than controls to report symptoms (e.g. fatigue, sore throat, fever, diarrhoea) of antecedent acute illness. Case-patients did not have a significantly greater prevalence or mean titre of IgG antibodies to respiratory syncytial virus, parainfluenza viruses, Epstein–Barr virus, and cytomegalovirus than controls. Serologic evidence of recent enterovirus infection (IgM antibodies) was found for 74% of case-patients compared with 54% of controls (P < 0·05), suggesting a possible association between vertigo and enterovirus infection. Future studies are needed to define the role of enteroviruses in inner-ear diseases.
Original languageEnglish
JournalEpidemiology and Infection
Volume117
Issue number1
ISSN0950-2688
DOIs
Publication statusPublished - 1996
Externally publishedYes

Cite this

Simonsen, L., Khan, A. S., Gary, H. E., Hanson, C., Pallansch, M. A., Music, S., ... Schonberger, L. B. (1996). Outbreak of vertigo in Wyoming: Possible role of an enterovirus infection. Epidemiology and Infection, 117(1). https://doi.org/10.1017/S0950268800001254
Simonsen, Lone ; Khan, A. S. ; Gary, H. E. ; Hanson, C. ; Pallansch, M. A. ; Music, S. ; Holman, Robert C. ; Stewart, A. ; Erdman, D. D. ; Arden, N. H. ; Arenberg, I. Kaufmann ; Schonberger, Lawrence B. / Outbreak of vertigo in Wyoming: Possible role of an enterovirus infection. In: Epidemiology and Infection. 1996 ; Vol. 117, No. 1.
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title = "Outbreak of vertigo in Wyoming: Possible role of an enterovirus infection",
abstract = "An epidemiologic investigation was conducted to characterize and evaluate the possibility of a viral aetiology of an outbreak of acute vertigo in Hot Springs Country, Wyoming, during autumn 1992. Case-finding identified Hot Springs County residents who sought medical attention for new onset vertigo during 1 August, 1992–31 January 1993. Thirty-five case-patients and 61 matched controls were interviewed and serum specimens were obtained during January 1993. Case-patients were more likely than controls to report symptoms (e.g. fatigue, sore throat, fever, diarrhoea) of antecedent acute illness. Case-patients did not have a significantly greater prevalence or mean titre of IgG antibodies to respiratory syncytial virus, parainfluenza viruses, Epstein–Barr virus, and cytomegalovirus than controls. Serologic evidence of recent enterovirus infection (IgM antibodies) was found for 74{\%} of case-patients compared with 54{\%} of controls (P < 0·05), suggesting a possible association between vertigo and enterovirus infection. Future studies are needed to define the role of enteroviruses in inner-ear diseases.",
author = "Lone Simonsen and Khan, {A. S.} and Gary, {H. E.} and C. Hanson and Pallansch, {M. A.} and S. Music and Holman, {Robert C.} and A. Stewart and Erdman, {D. D.} and Arden, {N. H.} and Arenberg, {I. Kaufmann} and Schonberger, {Lawrence B.}",
year = "1996",
doi = "10.1017/S0950268800001254",
language = "English",
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Simonsen, L, Khan, AS, Gary, HE, Hanson, C, Pallansch, MA, Music, S, Holman, RC, Stewart, A, Erdman, DD, Arden, NH, Arenberg, IK & Schonberger, LB 1996, 'Outbreak of vertigo in Wyoming: Possible role of an enterovirus infection', Epidemiology and Infection, vol. 117, no. 1. https://doi.org/10.1017/S0950268800001254

Outbreak of vertigo in Wyoming: Possible role of an enterovirus infection. / Simonsen, Lone; Khan, A. S.; Gary, H. E.; Hanson, C.; Pallansch, M. A.; Music, S.; Holman, Robert C.; Stewart, A.; Erdman, D. D.; Arden, N. H.; Arenberg, I. Kaufmann; Schonberger, Lawrence B.

In: Epidemiology and Infection, Vol. 117, No. 1, 1996.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Outbreak of vertigo in Wyoming: Possible role of an enterovirus infection

AU - Simonsen, Lone

AU - Khan, A. S.

AU - Gary, H. E.

AU - Hanson, C.

AU - Pallansch, M. A.

AU - Music, S.

AU - Holman, Robert C.

AU - Stewart, A.

AU - Erdman, D. D.

AU - Arden, N. H.

AU - Arenberg, I. Kaufmann

AU - Schonberger, Lawrence B.

PY - 1996

Y1 - 1996

N2 - An epidemiologic investigation was conducted to characterize and evaluate the possibility of a viral aetiology of an outbreak of acute vertigo in Hot Springs Country, Wyoming, during autumn 1992. Case-finding identified Hot Springs County residents who sought medical attention for new onset vertigo during 1 August, 1992–31 January 1993. Thirty-five case-patients and 61 matched controls were interviewed and serum specimens were obtained during January 1993. Case-patients were more likely than controls to report symptoms (e.g. fatigue, sore throat, fever, diarrhoea) of antecedent acute illness. Case-patients did not have a significantly greater prevalence or mean titre of IgG antibodies to respiratory syncytial virus, parainfluenza viruses, Epstein–Barr virus, and cytomegalovirus than controls. Serologic evidence of recent enterovirus infection (IgM antibodies) was found for 74% of case-patients compared with 54% of controls (P < 0·05), suggesting a possible association between vertigo and enterovirus infection. Future studies are needed to define the role of enteroviruses in inner-ear diseases.

AB - An epidemiologic investigation was conducted to characterize and evaluate the possibility of a viral aetiology of an outbreak of acute vertigo in Hot Springs Country, Wyoming, during autumn 1992. Case-finding identified Hot Springs County residents who sought medical attention for new onset vertigo during 1 August, 1992–31 January 1993. Thirty-five case-patients and 61 matched controls were interviewed and serum specimens were obtained during January 1993. Case-patients were more likely than controls to report symptoms (e.g. fatigue, sore throat, fever, diarrhoea) of antecedent acute illness. Case-patients did not have a significantly greater prevalence or mean titre of IgG antibodies to respiratory syncytial virus, parainfluenza viruses, Epstein–Barr virus, and cytomegalovirus than controls. Serologic evidence of recent enterovirus infection (IgM antibodies) was found for 74% of case-patients compared with 54% of controls (P < 0·05), suggesting a possible association between vertigo and enterovirus infection. Future studies are needed to define the role of enteroviruses in inner-ear diseases.

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DO - 10.1017/S0950268800001254

M3 - Journal article

VL - 117

JO - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

IS - 1

ER -