On prediction of OH stretching frequencies in intramolecularly hydrogen bonded systems

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OH stretching frequencies are investigated for a series of non-tautomerizing systems with intramolecular hydrogen bonds. Effective OH stretching wavenumbers are predicted by the application of empirical correlation procedures based on the results of B3LYP/6-31G(d) theoretical calculations in the harmonic and PT2 anharmonic approximations, as well as on experimental NMR parameters, i.e., proton chemical shifts (δH) and two-bond deuterium isotope effects on 13C chemical shifts (2ΔCOD). The procedures are applied in a discussion of the spectra of 2,6-dihydroxy-4-methylbenzaldehyde and 8-hydroxyquinoline N-oxide. The spectrum of the former displays a broad, composite band between 3500 and 2500 cm–1 which can be assigned to overlapping monomer and dimer contributions. In the latter case, the results support a reassignment of the OH stretching band of 8-hydroxyquinoline N-oxide; the reassignment is supported by correlation with the IR spectra of a series of substituted derivatives.

Original languageEnglish
JournalJournal of Molecular Structure: THEOCHEM
Pages (from-to)8-13
Number of pages6
Publication statusPublished - 27 Jun 2012


  • OH stretching frequencies
  • Two-bond isotope effects
  • OH chemical shifts
  • DFT calculations
  • Intramolecular hydrogen bonding

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