Nye molekylære markører ved de kroniske myeloproliferative sygdomme: I. Polycythaemia rubra vera-1-genet

Translated title of the contribution: New molecular markers within the chronic myeloproliferative disorders. I: The PRV-1 gene

Thomas Stauffer Larsen*, Niels Pallisgaard, Jacob Haaber Christensen, Paul Gram-Hansen, Gitte B. Kerndrup, Michael Boe Møller, Hans Carl Hasselbalch

*Corresponding author for this work

Research output: Contribution to journalReviewpeer-review

Abstract

PRV-1 is a new molecular marker within the Ph-negative chronic myeloproliferative disorders. PRV-1 is a useful, highly sensitive and specific marker in the differentiation between polycythaemia vera (PV) and secondary erythrocytosis (ET), and seems to identify those PV patients presenting in the early phase of the disease with dominating thrombocytosis and thus a clinical phenotype of ET. These PRV-1 positive ET patients can be regarded as having "masked" PV or, more accurately, as having early PV. Moreover, PRV-1 positivity may be associated with a particular risk of thromboembolic complications. The biological role of PRV-1 and the significance of alterations in PRV-1 gene expression levels during treatment remain to be clarified.

Translated title of the contributionNew molecular markers within the chronic myeloproliferative disorders. I: The PRV-1 gene
Original languageDanish
JournalUgeskrift for Laeger
Volume168
Issue number39
Pages (from-to)3295-3299
Number of pages5
ISSN0041-5782
Publication statusPublished - 25 Sep 2006
Externally publishedYes

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