Mitogen activated protein kinases: A role in inflammatory bowel disease?

O. J. Broom, B. Widjaya, J. Troelsen, J. Olsen, O. H. Nielsen

Research output: Contribution to journalReviewResearchpeer-review

Abstract

Since their discovery more than 15 years ago, the mitogen activated protein kinases (MAPK) have been implicated in an ever-increasingly diverse array of pathways, including inflammatory signalling cascades. Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are characterized by the perpetual production of inflammatory mediators. Research into the transduction pathway behind this over-production has highlighted the potential mediating role for the MAPKs and their related signalling components. This review highlights some of the research into the role for the MAPKs and their related signalling proteins in influencing the progression of IBD.

Original languageEnglish
JournalClinical and Experimental Immunology
Volume158
Issue number3
Pages (from-to)272-280
Number of pages9
ISSN0009-9104
DOIs
Publication statusPublished - Dec 2009
Externally publishedYes

Keywords

  • Inflammation
  • Inflammatory bowel disease
  • MAP kinase

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