Miliutine A acid, a new cyclofarnesane sesquiterpene from the stems of Miliusa velutina

Hoang Khang Le, Thanh Tung Phan, Thi Kieu Loan Vo, Thi Thuy Duong Ngo, Hoang Long Ngo, Poul Erik Hansen, Quang Ton That*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Six compounds were isolated from the ethyl acetate extract of the stems of Miliusa velutina, including miliutine A acid (1), a new cyclofarnesane sesquiterpenoid; miliutine B methyl ester (2), a cyclofarnesane sesquiterpenoid which was determined the absolute configuration for the first time and four known phenol derivatives (3–6). NMR spectroscopic and mass spectrometry were used for identifying relative configurations. The assignments of the absolute configurations were determined based on Electronic Circular Dichroism (ECD) and NOESY spectra analysis. All six compounds were screened for their in vitro cytotoxic activities against HepG2 cell line using the SRB assay and they showed weak or none activities.
Original languageEnglish
JournalNatural Product Research
Volume39
Issue number1
Pages (from-to)31-38
Number of pages8
ISSN1478-6419
DOIs
Publication statusPublished - 2025

Keywords

  • cyclofarnesane
  • ECD spectrum
  • structure determinaton
  • Miliusa velutina
  • miliutine A acid
  • sesquiterpene

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