Long-term residential exposure to air pollution and Hodgkin lymphoma risk among adults in Denmark: a population-based case–control study

Tahir Taj; Aslak Harbo Poulsen; Matthias Ketzel; Camilla Geels; Jørgen Brandt; Jesper Heile Christensen; Ulla Arthur Hvidtfeldt; Mette Sørensen; Ole Raaschou-Nielsen

doi:10.1007/s10552-021-01446-w

Long-term residential exposure to air pollution and Hodgkin lymphoma risk among adults in Denmark: a population-based case–control study

Tahir Taj^*, Aslak Harbo Poulsen, Matthias Ketzel, Camilla Geels, Jørgen Brandt, Jesper Heile Christensen, Ulla Arthur Hvidtfeldt, Mette Sørensen, Ole Raaschou-Nielsen

^*Corresponding author for this work

Department of Science and Environment

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Purpose: The etiology of Hodgkin lymphoma (HL) is obscure. Research on air pollution and risk of HL provides inconsistent results. We aimed to investigate the association between long-term residential exposure to air pollution and risk of adult Hodgkin lymphoma in Denmark. Methods: We performed a nationwide register-based case–control study, including all (n = 2,681) Hodgkin lymphoma cases registered in the nationwide Danish Cancer Registry between 1989 and 2014. We randomly selected 8,853 age- and sex-matched controls from the entire Danish population using the Civil Registration System, and identified 20-year residential address history for all cases and controls. We modeled outdoor air pollution concentrations at all these addresses using the high-resolution multiscale air pollution model system DEHM/UBM/AirGIS. We used conditional logistic regression to estimate odds ratios adjusted for individual and neighborhood level sociodemographic variables. Results: There was no association between 1, 5, 10, and 20 years’ time-weighted average exposure to fine particles (PM_2.5), O₃, SO_2, NO_2, or the PM_2.5 constituents OC, NH₄, NO₃, and SO₄ and risk of Hodgkin lymphoma. Conclusion: Residential exposure to ambient air pollution does not seem to increase the risk of developing Hodgkin lymphoma.

Original language	English
Journal	Cancer Causes and Control
Volume	32
Issue number	9
Pages (from-to)	935-942
Number of pages	8
ISSN	0957-5243
DOIs	https://doi.org/10.1007/s10552-021-01446-w
Publication status	Published - Sept 2021

Bibliographical note

Funding Information:
The research was funded by Nordforsk under the Nordic Programme on Health and Welfare (Project #75007: NordicWelfAir—Understanding the link between Air pollution and Distribution of related Health Impacts and Welfare in the Nordic countries).G.

Keywords

Air pollution
Case–control
Hodgkin lymphoma
Long-term exposure

Link to document

10.1007/s10552-021-01446-w

Cite this

Taj, T., Poulsen, A. H., Ketzel, M., Geels, C., Brandt, J., Christensen, J. H., Hvidtfeldt, U. A., Sørensen, M., & Raaschou-Nielsen, O. (2021). Long-term residential exposure to air pollution and Hodgkin lymphoma risk among adults in Denmark: a population-based case–control study. Cancer Causes and Control, 32(9), 935-942. https://doi.org/10.1007/s10552-021-01446-w

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title = "Long-term residential exposure to air pollution and Hodgkin lymphoma risk among adults in Denmark: a population-based case–control study",

abstract = "Purpose: The etiology of Hodgkin lymphoma (HL) is obscure. Research on air pollution and risk of HL provides inconsistent results. We aimed to investigate the association between long-term residential exposure to air pollution and risk of adult Hodgkin lymphoma in Denmark. Methods: We performed a nationwide register-based case–control study, including all (n = 2,681) Hodgkin lymphoma cases registered in the nationwide Danish Cancer Registry between 1989 and 2014. We randomly selected 8,853 age- and sex-matched controls from the entire Danish population using the Civil Registration System, and identified 20-year residential address history for all cases and controls. We modeled outdoor air pollution concentrations at all these addresses using the high-resolution multiscale air pollution model system DEHM/UBM/AirGIS. We used conditional logistic regression to estimate odds ratios adjusted for individual and neighborhood level sociodemographic variables. Results: There was no association between 1, 5, 10, and 20 years{\textquoteright} time-weighted average exposure to fine particles (PM2.5), O3, SO2, NO2, or the PM2.5 constituents OC, NH4, NO3, and SO4 and risk of Hodgkin lymphoma. Conclusion: Residential exposure to ambient air pollution does not seem to increase the risk of developing Hodgkin lymphoma.",

keywords = "Air pollution, Case–control, Hodgkin lymphoma, Long-term exposure, Air pollution, Case–control, Hodgkin lymphoma, Long-term exposure",

author = "Tahir Taj and Poulsen, {Aslak Harbo} and Matthias Ketzel and Camilla Geels and J{\o}rgen Brandt and Christensen, {Jesper Heile} and Hvidtfeldt, {Ulla Arthur} and Mette S{\o}rensen and Ole Raaschou-Nielsen",

note = "Funding Information: The research was funded by Nordforsk under the Nordic Programme on Health and Welfare (Project #75007: NordicWelfAir—Understanding the link between Air pollution and Distribution of related Health Impacts and Welfare in the Nordic countries).G.",

year = "2021",

month = sep,

doi = "10.1007/s10552-021-01446-w",

language = "English",

volume = "32",

pages = "935--942",

journal = "Cancer Causes and Control",

issn = "0957-5243",

publisher = "Springer Netherlands",

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TY - JOUR

T1 - Long-term residential exposure to air pollution and Hodgkin lymphoma risk among adults in Denmark

T2 - a population-based case–control study

AU - Taj, Tahir

AU - Poulsen, Aslak Harbo

AU - Ketzel, Matthias

AU - Geels, Camilla

AU - Brandt, Jørgen

AU - Christensen, Jesper Heile

AU - Hvidtfeldt, Ulla Arthur

AU - Sørensen, Mette

AU - Raaschou-Nielsen, Ole

N1 - Funding Information: The research was funded by Nordforsk under the Nordic Programme on Health and Welfare (Project #75007: NordicWelfAir—Understanding the link between Air pollution and Distribution of related Health Impacts and Welfare in the Nordic countries).G.

PY - 2021/9

Y1 - 2021/9

N2 - Purpose: The etiology of Hodgkin lymphoma (HL) is obscure. Research on air pollution and risk of HL provides inconsistent results. We aimed to investigate the association between long-term residential exposure to air pollution and risk of adult Hodgkin lymphoma in Denmark. Methods: We performed a nationwide register-based case–control study, including all (n = 2,681) Hodgkin lymphoma cases registered in the nationwide Danish Cancer Registry between 1989 and 2014. We randomly selected 8,853 age- and sex-matched controls from the entire Danish population using the Civil Registration System, and identified 20-year residential address history for all cases and controls. We modeled outdoor air pollution concentrations at all these addresses using the high-resolution multiscale air pollution model system DEHM/UBM/AirGIS. We used conditional logistic regression to estimate odds ratios adjusted for individual and neighborhood level sociodemographic variables. Results: There was no association between 1, 5, 10, and 20 years’ time-weighted average exposure to fine particles (PM2.5), O3, SO2, NO2, or the PM2.5 constituents OC, NH4, NO3, and SO4 and risk of Hodgkin lymphoma. Conclusion: Residential exposure to ambient air pollution does not seem to increase the risk of developing Hodgkin lymphoma.

AB - Purpose: The etiology of Hodgkin lymphoma (HL) is obscure. Research on air pollution and risk of HL provides inconsistent results. We aimed to investigate the association between long-term residential exposure to air pollution and risk of adult Hodgkin lymphoma in Denmark. Methods: We performed a nationwide register-based case–control study, including all (n = 2,681) Hodgkin lymphoma cases registered in the nationwide Danish Cancer Registry between 1989 and 2014. We randomly selected 8,853 age- and sex-matched controls from the entire Danish population using the Civil Registration System, and identified 20-year residential address history for all cases and controls. We modeled outdoor air pollution concentrations at all these addresses using the high-resolution multiscale air pollution model system DEHM/UBM/AirGIS. We used conditional logistic regression to estimate odds ratios adjusted for individual and neighborhood level sociodemographic variables. Results: There was no association between 1, 5, 10, and 20 years’ time-weighted average exposure to fine particles (PM2.5), O3, SO2, NO2, or the PM2.5 constituents OC, NH4, NO3, and SO4 and risk of Hodgkin lymphoma. Conclusion: Residential exposure to ambient air pollution does not seem to increase the risk of developing Hodgkin lymphoma.

KW - Air pollution

KW - Case–control

KW - Hodgkin lymphoma

KW - Long-term exposure

KW - Air pollution

KW - Case–control

KW - Hodgkin lymphoma

KW - Long-term exposure

U2 - 10.1007/s10552-021-01446-w

DO - 10.1007/s10552-021-01446-w

M3 - Journal article

C2 - 34050843

AN - SCOPUS:85107025944

SN - 0957-5243

VL - 32

SP - 935

EP - 942

JO - Cancer Causes and Control

JF - Cancer Causes and Control

IS - 9

ER -