Lack of the RNA chaperone hfq attenuates pathogenicity of several Escherichia coli pathotypes towards Caenorhabditis elegans

Martin Saxtorph Bojer, Henrik Jakobsen, Carsten Struve, Karen A. Krogfelt, Anders Løbner-Olesen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Escherichia coli is an important agent of Gram-negative bacterial infections worldwide, being one of the leading causes of diarrhoea and urinary tract infections. Strategies to understand pathogenesis and develop therapeutic compounds include the use of the nematode Caenorhabditis elegans as a model for virulence characterization and screening for novel antimicrobial entities. Several E. coli human pathotypes are also pathogenic towards C. elegans, and we show here that lack of the RNA chaperone Hfq significantly reduces pathogenicity of VTEC, EAEC, and UPEC in the nematode model. Thus, Hfq is intrinsically essential to pathogenic E. coli for survival and virulence exerted in the C. elegans host.
    Original languageEnglish
    JournalMicrobes and Infection
    Volume14
    Issue number12
    Pages (from-to)1034-1039
    ISSN1286-4579
    DOIs
    Publication statusPublished - 2012

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