Isolation and preparation of cytotoxic chromanone acids from the bark of Calophyllum dongnaiense

Tri Hieu Nguyen; Poul Erik Hansen; Fritz Duus; Gørg Heilmann; Dinh Hung Pham; Lien Hoa Dieu Nguyen

Isolation and preparation of cytotoxic chromanone acids from the bark of Calophyllum dongnaiense

Tri Hieu Nguyen, Poul Erik Hansen, Fritz Duus, Gørg Heilmann, Dinh Hung Pham, Lien Hoa Dieu Nguyen

Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Three chromanone acids, blancoic acid (1), isoblancoic acid (2) and chapelieric acid (3), were isolated from the bark of Calophyllum dongnaiense Pierre collected in Dong Nai Province. Their structures were elucidated using spectroscopic techniques (1-D and 2-D NMR, UV, IR and MS) as well as chemical methods. Cytotoxicity of compounds 1-3 and their 5-O-acetylated and methylated derivatives against Hela cell line was examined.

Original language	Vietnamese
Journal	Journal of Chemistry
Volume	47
Pages (from-to)	347-51
Number of pages	5
ISSN	0866-7144
Publication status	Published - 2009

Keywords

Cytotoxicity
Calophyllum dongnaiense
Blancoic acid

Cite this

@article{f993af70fa4011de89af000ea68e967b,

title = "Isolation and preparation of cytotoxic chromanone acids from the bark of Calophyllum dongnaiense",

abstract = "Three chromanone acids, blancoic acid (1), isoblancoic acid (2) and chapelieric acid (3), were isolated from the bark of Calophyllum dongnaiense Pierre collected in Dong Nai Province. Their structures were elucidated using spectroscopic techniques (1-D and 2-D NMR, UV, IR and MS) as well as chemical methods. Cytotoxicity of compounds 1-3 and their 5-O-acetylated and methylated derivatives against Hela cell line was examined.",

keywords = "Cytotoxicity, Calophyllum dongnaiense, Cytotoxicity, Calophyllum dongnaiense, Blancoic acid",

author = "Nguyen, {Tri Hieu} and Hansen, {Poul Erik} and Fritz Duus and G{\o}rg Heilmann and Pham, {Dinh Hung} and Nguyen, {Lien Hoa Dieu}",

year = "2009",

language = "Vietnamesisk",

volume = "47",

pages = "347--51",

journal = "Journal of Chemistry",

issn = "0866-7144",

publisher = "H{\`a}-n{\^o}i, Vi{\^e}n Khoa hoc Vi{\^e}t Nam",

}

TY - JOUR

T1 - Isolation and preparation of cytotoxic chromanone acids from the bark of Calophyllum dongnaiense

AU - Nguyen, Tri Hieu

AU - Hansen, Poul Erik

AU - Duus, Fritz

AU - Heilmann, Gørg

AU - Pham, Dinh Hung

AU - Nguyen, Lien Hoa Dieu

PY - 2009

Y1 - 2009

N2 - Three chromanone acids, blancoic acid (1), isoblancoic acid (2) and chapelieric acid (3), were isolated from the bark of Calophyllum dongnaiense Pierre collected in Dong Nai Province. Their structures were elucidated using spectroscopic techniques (1-D and 2-D NMR, UV, IR and MS) as well as chemical methods. Cytotoxicity of compounds 1-3 and their 5-O-acetylated and methylated derivatives against Hela cell line was examined.

AB - Three chromanone acids, blancoic acid (1), isoblancoic acid (2) and chapelieric acid (3), were isolated from the bark of Calophyllum dongnaiense Pierre collected in Dong Nai Province. Their structures were elucidated using spectroscopic techniques (1-D and 2-D NMR, UV, IR and MS) as well as chemical methods. Cytotoxicity of compounds 1-3 and their 5-O-acetylated and methylated derivatives against Hela cell line was examined.

KW - Cytotoxicity

KW - Calophyllum dongnaiense

KW - Cytotoxicity

KW - Calophyllum dongnaiense

KW - Blancoic acid

M3 - Tidsskriftartikel

SN - 0866-7144

VL - 47

SP - 347

EP - 351

JO - Journal of Chemistry

JF - Journal of Chemistry

ER -