Interplay of mitochondrial metabolism and microRNAs

Julian Geiger, Louise Torp Dalgaard

Research output: Contribution to journalReviewResearchpeer-review

Abstract

Mitochondria are important organelles in cellular metabolism. Several crucial metabolic pathways such as the energy producing electron transport chain or the tricarboxylic acid cycle are hosted inside the mitochondria. The proper function of mitochondria depends on the import of proteins, which are encoded in the nucleus and synthesized in the cytosol. Micro-ribonucleic acids (miRNAs) are short non-coding ribonucleic acid (RNA) molecules with the ability to prevent messenger RNA (mRNA)-translation or to induce the degradation of mRNA-transcripts. Although miRNAs are mainly located in the cytosol or the nucleus, a subset of ~150 different miRNAs, called mitomiRs, has also been found localized to mitochondrial fractions of cells and tissues together with the subunits of the RNA-induced silencing complex (RISC); the protein complex through which miRNAs normally act to prevent translation of their mRNA-targets. The focus of this review is on miRNAs and mitomiRs with influence on mitochondrial metabolism and their possible pathophysiological impact.
Original languageEnglish
JournalCellular and Molecular Life Sciences
Volume74
Issue number4
Pages (from-to)631-646
Number of pages16
ISSN1420-682X
DOIs
Publication statusPublished - Feb 2017

Bibliographical note

This article has been found as Bronze Open Access on February 2nd 2018. I f the access to this article closes, please notify rucforsk@ruc.dk

Keywords

  • Mitochondria
  • miRNA
  • Metabolism
  • mitomiR

Cite this