Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB.

Stephane Duigou, Kristine Groth Knudsen, Ole Skovgaard, Elisabeth S. Egan, Anders Løbner-Olesen, Matthew K Waldor

    Research output: Contribution to journalJournal articlepeer-review


    Although the two Vibrio cholerae chromosomes initiate replication in a coordinated fashion, we show here that each chromosome appears to have a specific replication initiator. DnaA overproduction promoted overinitiation of chromosome I and not chromosome II. In contrast, overproduction of RctB, a protein that binds to the origin of replication of chromosome II, promoted overinitiation of chromosome II and not chromosome I.
    Original languageEnglish
    JournalJournal of Bacteriology
    Issue number17
    Pages (from-to)6419-24
    Number of pages6
    Publication statusPublished - 2006

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