Functional Mitochondria Are Important for the Effect of Resveratrol

Anne Lykkegaard Widlund, Kaushal Baral, Louise Torp Dalgaard, Ole Vang

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Resveratrol (Resv) is a polyphenol reported to modulate mitochondrial activity. The aim was to use HeLa and 143B cells to characterize the action of Resv on mitochondrial activity, cell size and proliferation using wild type (WT) and Rho 0 cells deficient in mitochondrial DNA. In both HeLa WT and Rho 0 cells, the oxygen consumption rate (OCR) was increased at 20 µM Resv after 24 h, whereas only a non-significant increase of OCR was observed in 143B WT cells. Resv decreased cell number concentration-dependently in both WT and Rho 0 cell types. An increased cell diameter was observed in HeLa WT, but not in Rho 0 when treated with Resv. Overall, the findings presented indicate that functional mitochondria are a prerequisite for cell enlargement by Resv.
Original languageEnglish
Article number847
JournalMolecules
Volume22
Issue number5
ISSN1420-3049
DOIs
Publication statusPublished - May 2017

Keywords

  • 143B
  • HeLa
  • Rho 0
  • mitochondria
  • oxidative stress
  • oxygen consumption rate
  • resveratrol
  • wild type

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