ETS-family genes in pancreatic development

Sune Kobberup, Pia Nyeng, Kirstine Juhl, John Hutton, Jan Jensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

ETS-family factors play major roles in development and cancer, notably as critical targets for extra-cellular signaling pathways, including MAPK-signaling. Given the presently limited knowledge on the role of ETS-factors in pancreatic development, we here sought to characterize all 26 individual members of the ETS-family in relation to pancreatic development using a combination of genomics, RT-PCR, and histological techniques. This analysis uncovers 22 ETS family genes displaying select spatial and temporal expression patterns in the developing pancreas. Highly specific expression of ETS-family components is observed in pancreatic progenitor cells or the associated embryonic mesenchyme. Other members are linked to the differentiation of more mature pancreatic cells, including exocrine and endocrine cell types. We find that two members of the Etv subfamily, Etv4 and Etv5, are expressed in cells proximal to pancreatic mesenchyme, and, furthermore, induced in FGF10-arrested pancreatic progenitors suggesting that these factors mediate mesenchymal-to-epithelial signaling.
Original languageEnglish
JournalDevelopmental Dynamics
Volume236
Issue number11
ISSN1058-8388
DOIs
Publication statusPublished - 2007
Externally publishedYes

Cite this

Kobberup, Sune ; Nyeng, Pia ; Juhl, Kirstine ; Hutton, John ; Jensen, Jan. / ETS-family genes in pancreatic development. In: Developmental Dynamics. 2007 ; Vol. 236, No. 11.
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Kobberup, S, Nyeng, P, Juhl, K, Hutton, J & Jensen, J 2007, 'ETS-family genes in pancreatic development', Developmental Dynamics, vol. 236, no. 11. https://doi.org/10.1002/dvdy.21292

ETS-family genes in pancreatic development. / Kobberup, Sune; Nyeng, Pia; Juhl, Kirstine; Hutton, John; Jensen, Jan.

In: Developmental Dynamics, Vol. 236, No. 11, 2007.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - ETS-family genes in pancreatic development

AU - Kobberup, Sune

AU - Nyeng, Pia

AU - Juhl, Kirstine

AU - Hutton, John

AU - Jensen, Jan

PY - 2007

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N2 - ETS-family factors play major roles in development and cancer, notably as critical targets for extra-cellular signaling pathways, including MAPK-signaling. Given the presently limited knowledge on the role of ETS-factors in pancreatic development, we here sought to characterize all 26 individual members of the ETS-family in relation to pancreatic development using a combination of genomics, RT-PCR, and histological techniques. This analysis uncovers 22 ETS family genes displaying select spatial and temporal expression patterns in the developing pancreas. Highly specific expression of ETS-family components is observed in pancreatic progenitor cells or the associated embryonic mesenchyme. Other members are linked to the differentiation of more mature pancreatic cells, including exocrine and endocrine cell types. We find that two members of the Etv subfamily, Etv4 and Etv5, are expressed in cells proximal to pancreatic mesenchyme, and, furthermore, induced in FGF10-arrested pancreatic progenitors suggesting that these factors mediate mesenchymal-to-epithelial signaling.

AB - ETS-family factors play major roles in development and cancer, notably as critical targets for extra-cellular signaling pathways, including MAPK-signaling. Given the presently limited knowledge on the role of ETS-factors in pancreatic development, we here sought to characterize all 26 individual members of the ETS-family in relation to pancreatic development using a combination of genomics, RT-PCR, and histological techniques. This analysis uncovers 22 ETS family genes displaying select spatial and temporal expression patterns in the developing pancreas. Highly specific expression of ETS-family components is observed in pancreatic progenitor cells or the associated embryonic mesenchyme. Other members are linked to the differentiation of more mature pancreatic cells, including exocrine and endocrine cell types. We find that two members of the Etv subfamily, Etv4 and Etv5, are expressed in cells proximal to pancreatic mesenchyme, and, furthermore, induced in FGF10-arrested pancreatic progenitors suggesting that these factors mediate mesenchymal-to-epithelial signaling.

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