Ethylene oxide graft copolymers reduce the immunogenicity of lipid nanoparticles

Yalin Qi; Hesong Han; Albert Liu; Sheng Zhao; Atip Lawanprasert; Josefine Eilsø Nielsen; Hema Choudhary; Dengpan Liang; Annelise E. Barron; Niren Murthy

doi:10.1039/d4ra05007j

Ethylene oxide graft copolymers reduce the immunogenicity of lipid nanoparticles

Yalin Qi
, Hesong Han
, Albert Liu
, Sheng Zhao
, Atip Lawanprasert
, Josefine Eilsø Nielsen
, Hema Choudhary
, Dengpan Liang
, Annelise E. Barron
, Niren Murthy^*

^*Corresponding author

Department of Science and Environment

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

12 Downloads (Pure)

Abstract

Lipid nanoparticle (LNP)/mRNA complexes have great therapeutic potential but their PEG chains can induce the production of anti-PEG antibodies. New LNPs that do not contain PEG are greatly needed. We demonstrate here that poly-glutamic acid-ethylene oxide graft copolymers can replace the PEG on LNPs and outperform PEG-LNPs after chronic administration.

Original language	English
Journal	RSC Advances
Volume	14
Issue number	41
Pages (from-to)	30071-30076
Number of pages	6
ISSN	2046-2069
DOIs	https://doi.org/10.1039/d4ra05007j
Publication status	Published - 20 Sept 2024

Access to Document

10.1039/d4ra05007jLicence: CC BY-NC

Ethylene oxide graft copolymers reduce the immunogenicity of lipid nanoparticlesFinal published version, 822 KBLicence: CC BY-NC

Citation Styles

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abstract = "Lipid nanoparticle (LNP)/mRNA complexes have great therapeutic potential but their PEG chains can induce the production of anti-PEG antibodies. New LNPs that do not contain PEG are greatly needed. We demonstrate here that poly-glutamic acid-ethylene oxide graft copolymers can replace the PEG on LNPs and outperform PEG-LNPs after chronic administration.",

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T1 - Ethylene oxide graft copolymers reduce the immunogenicity of lipid nanoparticles

AU - Qi, Yalin

AU - Han, Hesong

AU - Liu, Albert

AU - Zhao, Sheng

AU - Lawanprasert, Atip

AU - Nielsen, Josefine Eilsø

AU - Choudhary, Hema

AU - Liang, Dengpan

AU - Barron, Annelise E.

AU - Murthy, Niren

PY - 2024/9/20

Y1 - 2024/9/20

N2 - Lipid nanoparticle (LNP)/mRNA complexes have great therapeutic potential but their PEG chains can induce the production of anti-PEG antibodies. New LNPs that do not contain PEG are greatly needed. We demonstrate here that poly-glutamic acid-ethylene oxide graft copolymers can replace the PEG on LNPs and outperform PEG-LNPs after chronic administration.

AB - Lipid nanoparticle (LNP)/mRNA complexes have great therapeutic potential but their PEG chains can induce the production of anti-PEG antibodies. New LNPs that do not contain PEG are greatly needed. We demonstrate here that poly-glutamic acid-ethylene oxide graft copolymers can replace the PEG on LNPs and outperform PEG-LNPs after chronic administration.

U2 - 10.1039/d4ra05007j

DO - 10.1039/d4ra05007j

M3 - Journal article

AN - SCOPUS:85204875303

SN - 2046-2069

VL - 14

SP - 30071

EP - 30076

JO - RSC Advances

JF - RSC Advances

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