Early identification of non-remission in first-episode psychosis in a two-year outcome study

Erik Simonsen, Svein Friis, Stein Opjordsmoen, Erik Lykke Mortensen, Ulrik Haahr, Ingrid Melle, Inge Joa, Jan Olav Johannessen, Tor Ketil Larsen, Jan Ivar Røssberg, Bjørn Rishovd Rund, Per Vaglum, Thomas H. McGlashan

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    Objective: to identify predictors of non-remission in first-episode, non-affective psychosis.
    Method: During 4 years, we recruited 301 patients consecutively. Information about first remission at 3 months was available for 299 and at 2 years for 293 cases. Symptomatic and social outcomes were assessed at 3 months, 1 and 2 years.
    Results: One hundred and twenty-nine patients (43%) remained psychotic at 3 months and 48 patients (16.4%) remained psychotid over 2 years. When we compared premorbid and baseline data for the three groups, the non-remitted (n=48), remitted for <6 months (n=38) and for more than 6 months (n=207), duration of untreated psychosis (DUP) was the only variable that significantly differentiated the groups (median DUP: 25.5, 14.4 and 6.0 weeks), respectively). Three months univariate predictors of non-remission were being single, longer DUP, core schizophrenia, and less excitative and more negative symptoms at baseline. Two-year predictors were younger age, being single and male, deteriorating premorbid social functioning, longer DUP and core schizophrenia. In multivariate analyses DUP, negative and excitative symptoms predicted non-remission at 3 months, but only DUP predicted at 2 years.
    Conclusion: Long DUP predicted both 3 month and 2-year non-remission rates in first-episode psychosis.
    Original languageEnglish
    JournalActa Psychiatrica Scandinavica
    Issue number5
    Pages (from-to)375-383
    Number of pages8
    Publication statusPublished - Nov 2010

    Cite this

    Simonsen, E., Friis, S., Opjordsmoen, S., Mortensen, E. L., Haahr, U., Melle, I., ... McGlashan, T. H. (2010). Early identification of non-remission in first-episode psychosis in a two-year outcome study. Acta Psychiatrica Scandinavica, 122(5), 375-383. https://doi.org/10.1111/j.1600-0447.2010.01598.x