Early Ascaris suum migration in mice as a model for pigs

H. C. Slotved; L. Eriksen; K. D. Murrell; P. Nansen

doi:10.2307/3284520

Early Ascaris suum migration in mice as a model for pigs

H. C. Slotved^*, L. Eriksen, K. D. Murrell, P. Nansen

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A study was made of the early migratory pattern of Ascaris suum in mice. Mice were each inoculated orally with a single dose of 2,500 infective eggs and then killed at 2, 4, 6, 8, 10, and 12 hr postinoculation (PI). At necropsy, it was observed that the larvae had penetrated the mouse cecum and colon and had reached the liver by 4 hr PI. This migratory behavior closely mimics what is observed in the pig and suggests that the mouse may serve as an experimental model for intestinal immunity in the early phase of A. suum infection.

Original language	English
Journal	Journal of Parasitology
Volume	84
Issue number	1
Pages (from-to)	16-18
Number of pages	3
ISSN	0022-3395
DOIs	https://doi.org/10.2307/3284520
Publication status	Published - Feb 1998
Externally published	Yes

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10.2307/3284520

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title = "Early Ascaris suum migration in mice as a model for pigs",

abstract = "A study was made of the early migratory pattern of Ascaris suum in mice. Mice were each inoculated orally with a single dose of 2,500 infective eggs and then killed at 2, 4, 6, 8, 10, and 12 hr postinoculation (PI). At necropsy, it was observed that the larvae had penetrated the mouse cecum and colon and had reached the liver by 4 hr PI. This migratory behavior closely mimics what is observed in the pig and suggests that the mouse may serve as an experimental model for intestinal immunity in the early phase of A. suum infection.",

author = "Slotved, {H. C.} and L. Eriksen and Murrell, {K. D.} and P. Nansen",

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AU - Slotved, H. C.

AU - Eriksen, L.

AU - Murrell, K. D.

AU - Nansen, P.

PY - 1998/2

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AB - A study was made of the early migratory pattern of Ascaris suum in mice. Mice were each inoculated orally with a single dose of 2,500 infective eggs and then killed at 2, 4, 6, 8, 10, and 12 hr postinoculation (PI). At necropsy, it was observed that the larvae had penetrated the mouse cecum and colon and had reached the liver by 4 hr PI. This migratory behavior closely mimics what is observed in the pig and suggests that the mouse may serve as an experimental model for intestinal immunity in the early phase of A. suum infection.

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JF - Journal of Parasitology

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Early Ascaris suum migration in mice as a model for pigs

Abstract

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