DNA damage, acetylcholinesterase activity and lysosomal stability in native and transplanted mussels (Mytilus edulis) in areas close to coastal chemical dumping sites in Denmark

Jette Rank, Kari K. Lehtonen, Jakob Strand, Martha Laursen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Biomarkers of genotoxicity (DNA damage, measured as tail moment in the Comet assay), neurotoxicity (acetylcholinesterase inhibition, AChE) and general stress (lysosomal membrane stability, LMS) were studied in native and transplanted blue mussels (Mytilus edulis) in coastal areas of western Denmark potentially affected by anthropogenic pollution originating from chemical dumping sites. The results indicate responses to pollution in all the biomarkers applied at the suspected areas, but the results were not consistent. Seasonal fluctuations in exposure situations at the study sites make interpretation of chemical pollution complex, as seen especially in the variability in results on DNA damage, and also in regard to AChE activity. These investigations further stress the importance of understanding the effects of natural factors (salinity, temperature, water levels, rain and storm events) in correct interpretation of the biomarker data obtained. In addition, adaptation of populations to local contamination may play a role in some of the response patterns observed. © 2007 Elsevier B.V. All rights reserved

Original languageEnglish
JournalAquatic Toxicology
Volume84
Issue number1
Pages (from-to)50-61
Number of pages10
ISSN0166-445X
DOIs
Publication statusPublished - 2007

Keywords

  • DNA damage
  • Comet assay
  • Acetylcholinesterase activity
  • Lysosomal membrane stability
  • Biomarker
  • Pollution monitoring
  • Blue mussel
  • Mytilus edulis

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