Abstract
Two new geranylated xanthones, 6-O-methylcowanin (4) and oliverixanthone (5), along with five known
compounds, cowanin, rubraxanthone, cowaxanthone, cowanol, and β-mangostin, have been isolated from the
bark of Garcinia oliveri. For comparison of their biological activities, one mono- and seven di-O-alkylated
α-mangostin derivatives were synthesized from α-mangostin. The structures of all compounds were assigned by
spectroscopic methods (1D and 2D NMR and MS). Cytotoxicity of selected xanthones against MCF-7 and DLD-1
cell lines was examined. Evaluation of the structure–activity relationship showed that α-mangostin had the
strongest activity, and all the O-alkylated α-mangostin derivatives showed reduced activity compared to the naturally
occurring α-mangostin.
compounds, cowanin, rubraxanthone, cowaxanthone, cowanol, and β-mangostin, have been isolated from the
bark of Garcinia oliveri. For comparison of their biological activities, one mono- and seven di-O-alkylated
α-mangostin derivatives were synthesized from α-mangostin. The structures of all compounds were assigned by
spectroscopic methods (1D and 2D NMR and MS). Cytotoxicity of selected xanthones against MCF-7 and DLD-1
cell lines was examined. Evaluation of the structure–activity relationship showed that α-mangostin had the
strongest activity, and all the O-alkylated α-mangostin derivatives showed reduced activity compared to the naturally
occurring α-mangostin.
| Original language | English |
|---|---|
| Journal | Chemical & Pharmaceutical Bulletin |
| Volume | 57 |
| Issue number | 8 |
| Pages (from-to) | 830-834 |
| Number of pages | 5 |
| ISSN | 0009-2363 |
| Publication status | Published - 2009 |
Keywords
- Garcinia oliveri
- O-alkylated α-mangostin
- oliverixanthone
- 6-O-methylcowanin
- cytotoxicity
- xanthone