Current State of SLC and ABC Transporters in the Skin and Their Relation to Sweat Metabolites and Skin Diseases

Marcus Hughes, Eva Aryal, Elnaz Safari, Biljana Mojsoska, Håvard Jenssen, Bala Krishna Prabhala*

*Corresponding author

Research output: Contribution to journalReviewpeer-review

Abstract

With a relatively large surface area (2 m2) and 15% of total body mass, the skin forms the largest organ of the human body. The main functions of the skin include regulation of body temperature by insulation or sweating, regulation of the nervous system, regulation of water content, and protection against external injury. To perform these critical functions, the skin encodes genes for transporters responsible for the cellular trafficking of essential nutrients and metabolites to maintain cellular hemostasis. However, the knowledge on the expression, regulation, and function of these transporters is very limited and needs more work to elucidate how these transporters play a role both in disease progression and in healing. Furthermore, SLC and ABC transporters are understudied, and even less studied in skin. There are sparse reports on relation between transporters in skin and sweat metabolites. This mini review focuses on the current state of SLC and ABC transporters in the skin and their relation to sweat metabolites and skin diseases
Original languageEnglish
Article number9020023
JournalProteomes
Volume9
Issue number23
ISSN2227-7382
DOIs
Publication statusPublished - May 2021

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