Clinical Implications of Intestinal Stem Cell Markers in Colorectal Cancer

Maiken Lise Marcker Espersen; Jesper Olsen; Dorte Linnemann; Estrid Høgdall; Jesper Troelsen

doi:10.1016/j.clcc.2014.12.004

Clinical Implications of Intestinal Stem Cell Markers in Colorectal Cancer

Maiken Lise Marcker Espersen, Jesper Olsen, Dorte Linnemann, Estrid Høgdall, Jesper Troelsen

Research output: Contribution to journal › Review › peer-review

Abstract

Colorectal cancer (CRC) still has one of the highest incidence and mortality rate among cancers. Therefore, improved differential diagnostics and personalized treatment are still needed. Several intestinal stem cell markers have been found to be associated with CRC and might have a prognostic and predictive significance in CRC patients. This review provides an overview of the intestinal stem cell markers leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), B cell–specific Moloney murine leukemia virus insertion site 1 (BMI1), Musashi1 (MSI1), and sex-determining region y-box 9 (SOX9) and their implications in human CRC. The exact roles of the intestinal stem cell markers in CRC development and progression remain unclear; however, high expression of these stem cell markers have a potential prognostic significance and might be implicated in chemotherapy resistance

Original language	Danish
Journal	Clinical Colorectal Cancer
Volume	14
Issue number	2
Pages (from-to)	63-71
ISSN	1533-0028
DOIs	https://doi.org/10.1016/j.clcc.2014.12.004
Publication status	Published - 2015

Link to document

10.1016/j.clcc.2014.12.004Licence: CC BY-NC-ND

1-s2.0-S1533002814001352-mainFinal published version, 291 KBLicence: CC BY-NC-ND

Cite this

@article{e2a77a00c4a24d17a6b2e8f574eef983,

title = "Clinical Implications of Intestinal Stem Cell Markers in Colorectal Cancer",

abstract = "Colorectal cancer (CRC) still has one of the highest incidence and mortality rate among cancers. Therefore, improved differential diagnostics and personalized treatment are still needed. Several intestinal stem cell markers have been found to be associated with CRC and might have a prognostic and predictive significance in CRC patients. This review provides an overview of the intestinal stem cell markers leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), B cell–specific Moloney murine leukemia virus insertion site 1 (BMI1), Musashi1 (MSI1), and sex-determining region y-box 9 (SOX9) and their implications in human CRC. The exact roles of the intestinal stem cell markers in CRC development and progression remain unclear; however, high expression of these stem cell markers have a potential prognostic significance and might be implicated in chemotherapy resistance",

author = "Espersen, {Maiken Lise Marcker} and Jesper Olsen and Dorte Linnemann and Estrid H{\o}gdall and Jesper Troelsen",

year = "2015",

doi = "10.1016/j.clcc.2014.12.004",

language = "Dansk",

volume = "14",

pages = "63--71",

journal = "Clinical Colorectal Cancer",

issn = "1533-0028",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Clinical Implications of Intestinal Stem Cell Markers in Colorectal Cancer

AU - Espersen, Maiken Lise Marcker

AU - Olsen, Jesper

AU - Linnemann, Dorte

AU - Høgdall, Estrid

AU - Troelsen, Jesper

PY - 2015

Y1 - 2015

N2 - Colorectal cancer (CRC) still has one of the highest incidence and mortality rate among cancers. Therefore, improved differential diagnostics and personalized treatment are still needed. Several intestinal stem cell markers have been found to be associated with CRC and might have a prognostic and predictive significance in CRC patients. This review provides an overview of the intestinal stem cell markers leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), B cell–specific Moloney murine leukemia virus insertion site 1 (BMI1), Musashi1 (MSI1), and sex-determining region y-box 9 (SOX9) and their implications in human CRC. The exact roles of the intestinal stem cell markers in CRC development and progression remain unclear; however, high expression of these stem cell markers have a potential prognostic significance and might be implicated in chemotherapy resistance

AB - Colorectal cancer (CRC) still has one of the highest incidence and mortality rate among cancers. Therefore, improved differential diagnostics and personalized treatment are still needed. Several intestinal stem cell markers have been found to be associated with CRC and might have a prognostic and predictive significance in CRC patients. This review provides an overview of the intestinal stem cell markers leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), B cell–specific Moloney murine leukemia virus insertion site 1 (BMI1), Musashi1 (MSI1), and sex-determining region y-box 9 (SOX9) and their implications in human CRC. The exact roles of the intestinal stem cell markers in CRC development and progression remain unclear; however, high expression of these stem cell markers have a potential prognostic significance and might be implicated in chemotherapy resistance

U2 - 10.1016/j.clcc.2014.12.004

DO - 10.1016/j.clcc.2014.12.004

M3 - Review

SN - 1533-0028

VL - 14

SP - 63

EP - 71

JO - Clinical Colorectal Cancer

JF - Clinical Colorectal Cancer

IS - 2

ER -