Chelation therapy in intoxications with mercury, lead and copper

yang Cao, Marit Aralt Skaug, Ole Andersen, Jan Aaseth

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    Abstract

    In the present review we provide an update of the appropriate use of chelating agents in the treatment of intoxications with compounds of mercury, lead and copper. The relatively new chelators meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercapto-propanesulphonate (DMPS) can effectively mobilize deposits of mercury as well as of lead into the urine. These drugs can be administered orally and have relatively low toxicity compared to the classical antidote dimercaptopropanol (BAL). d-Penicillamine has been widely used in copper overload, although 2,3-dimercaptosuccinic acid or tetrathiomolybdate may be more suitable alternatives today. In copper-toxicity, a free radical scavenger might be recommended as adjuvant to the chelator therapy
    Original languageEnglish
    JournalJournal of Trace Elements in Medicine and Biology
    Volume31
    Pages (from-to)188-192
    ISSN0946-672X
    DOIs
    Publication statusPublished - 2015

    Bibliographical note

    Special Section: 10th Nordic Symposium on Trace Elements in Human Health and Disease, edited by Jan Aaseth

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