TY - JOUR
T1 - Biomarkers of Physical and Mental Health for Prediction of Parkinson's Disease
T2 - A Population-Based Study from 15 European Countries
AU - Hussain, M. Azhar
AU - Qaisar, Rizwan
AU - Karim, Asima
AU - Ahmad, Firdos
AU - Franzese, Fabio
AU - Alsaad, Saad M.
AU - Al-Masri, Abeer A.
AU - Alkahtani, Shaea A.
N1 - Funding Information:
Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the U.S. National Institute on Aging (U01_AG09740-13S2, P01_AG005842, P01_AG08291, P30_AG12815, R21_AG025169, Y1-AG-4553-01, IAG_BSR06-11, OGHA_04-064, HHSN271201300071C, RAG052527A), and from various national funding sources is gratefully acknowledged (see www.share-project.org). The authors extend their appreciation to the Researchers Supporting Project number (RSP2024R277), King Saud University, Riyadh, Saudi Arabia for funding the current study.
PY - 2024/4
Y1 - 2024/4
N2 - ObjectivesEarly diagnosis of Parkinson's disease (PD) is critical for optimal treatment. However, the predictive potential of physical and mental health in PD is poorly characterized.MethodsWe evaluated the potential of multiple demographic, physical, and mental factors in predicting the future onset of PD in older adults aged 50 years or older from 15 European countries. Individual study participants were followed over four waves of the Survey of Health, Ageing, and Retirement in Europe (SHARE) from 2013–2020.ResultsOf 57,980 study participants, 442 developed PD during the study period. We identified male sex and advancing age from the sixth decade of life onward as significant predictors of future PD. Among physical factors, a low handgrip strength (HGS; men <27 kg, women <16 kg), being bothered by frailty, and recent falls were significantly associated with future PD. Among mental factors, a higher depression (Euro-D depression score >6) emerged as an independent predictor of future PD. Finally, the presence of hypertension or Alzheimer's disease (AD) increases the risk of future PD.ConclusionsAltogether, male sex, advancing age, low HGS, frailty, depression, hypertension, and AD were identified as critical risk factors for future PD. Our results may be useful in the early identification and treatment of populations at risk for PD.
AB - ObjectivesEarly diagnosis of Parkinson's disease (PD) is critical for optimal treatment. However, the predictive potential of physical and mental health in PD is poorly characterized.MethodsWe evaluated the potential of multiple demographic, physical, and mental factors in predicting the future onset of PD in older adults aged 50 years or older from 15 European countries. Individual study participants were followed over four waves of the Survey of Health, Ageing, and Retirement in Europe (SHARE) from 2013–2020.ResultsOf 57,980 study participants, 442 developed PD during the study period. We identified male sex and advancing age from the sixth decade of life onward as significant predictors of future PD. Among physical factors, a low handgrip strength (HGS; men <27 kg, women <16 kg), being bothered by frailty, and recent falls were significantly associated with future PD. Among mental factors, a higher depression (Euro-D depression score >6) emerged as an independent predictor of future PD. Finally, the presence of hypertension or Alzheimer's disease (AD) increases the risk of future PD.ConclusionsAltogether, male sex, advancing age, low HGS, frailty, depression, hypertension, and AD were identified as critical risk factors for future PD. Our results may be useful in the early identification and treatment of populations at risk for PD.
KW - Biomarkers
KW - Parkinson's disease
KW - Risk score
KW - SHARE data
KW - Biomarkers
KW - Parkinson's disease
KW - Risk score
KW - SHARE data
U2 - 10.1016/j.arcmed.2024.102988
DO - 10.1016/j.arcmed.2024.102988
M3 - Journal article
C2 - 38518526
AN - SCOPUS:85188901394
SN - 0188-4409
VL - 55
JO - Archives of Medical Research
JF - Archives of Medical Research
IS - 3
M1 - 102988
ER -