Apathy in first episode psychosis patients: a ten year longitudinal follow-up study

Erik Simonsen, Julie Evensen, Jan Ivar Røsberg, Helene Barder, Ulrik Haahr, Wenche ten Welden Hegelstad, Inge Joa, Jan Olav Johannessen, Tor Ketil Larsen, Ingrid Melle, Stein Opjordsmoen, Bjørn Rishovd Rund, Ketil Sundet, Per Vaglum, Svein Friis, Thomas McGlashan

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    BACKGROUND:

    Apathy is a common symptom in first episode psychosis (FEP), and is associated with poor functioning. Prevalence and correlates of apathy 10 years after the first psychotic episode remain unexplored.

    OBJECTIVE:

    The aims of the study were twofold: 1) to examine prevalence and predictors of apathy at 10 years, and 2) to examine the relationship between apathy at 10 years and concurrent symptoms, functioning and outcome, including subjective quality of life.

    METHODS:

    Three-hundred-and-one patients with FEP were included at baseline, 186 participated in the 10 year follow-up. Of these, 178 patients completed the Apathy Evaluation Scale (AES-S-Apathy). Patients were classified as having apathy (AES-S-Apathy≥27) or not. The relationship between apathy and baseline variables (Demographics, Diagnosis, Duration of Untreated Psychosis), measures of symptomatology (Positive and Negative Syndrome Scale, Calgary Depression Scale for Schizophrenia), functioning (Global Assessment of Functioning Scale, Strauss Carpenter Level of Functioning Scale) and subjective quality of life (Lehman's Quality of Life Interview) were estimated through correlation analyses and blockwise multiple hierarchical regression analysis.

    RESULTS:

    Nearly 30% of patients met the threshold for being apathetic at follow-up. No baseline variables predicted apathy significantly at 10 years. Apathy was found to contribute independently to functioning and subjective quality of life, even when controlling for other significant correlates.

    CONCLUSIONS:

    Apathy is a common symptom in a FEP cohort 10 years after illness debut, and its presence relates to impaired functioning and poorer subjective quality of life.
    Original languageEnglish
    JournalSchizophrenia Research
    Volume136
    Issue number1-3
    Pages (from-to)19-24
    ISSN0920-9964
    DOIs
    Publication statusPublished - 2012

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