Antimicrobial beta-peptides and alpha-peptoids

Troels Godballe, Line L. Nilsson, Pernille D. Petersen, Håvard Jenssen

Research output: Contribution to journalReviewResearchpeer-review

Abstract

The field of drug discovery and development has seen tremendous activity over the past decade to better tackle the increasing occurrence of drugresistant
bacterial infections and to alleviate some of the pressure we put on the last-resort drugs on the market. One of the new and promising drug candidates is derived from naturally occurring antimicrobial peptides. However, despite promising results in early-stage clinical trials, these molecules have faced some difficulties securing FDA approval, which can be linked to their poor metabolic
stability. Hence, mimetics of these antimicrobial peptides have been suggested as new templates for antibacterial compound design, because these mimetics are resistant against degradation by proteases. This review will discuss the
structural features of two different types of mimetics, b-peptides and a-peptoids, in relation to their antibacterial activity and conclude on their
potential as new candidates for bacterial intervention
Original languageEnglish
JournalChemical Biology and Drug Design (Print)
Volume77
Issue number2
Pages (from-to)107-116
ISSN1747-0277
DOIs
Publication statusPublished - 2011

Keywords

  • α-peptoids
  • antibiotic resistance
  • antimicrobial peptides
  • β-peptide
  • drug design
  • peptidomimetics

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