Amide versus amine ligand paradigm in the direct amination of alcohols with Ru-PNP complexes

Dennis Pingen, Jong-Hoo Choi, Henry Allen, George Murray, Prasad Ganji, Piet W. N. M. Van Leeuwen, Martin H. G. Prechtl, Dieter Vogt

Research output: Contribution to journalJournal articlepeer-review


The catalytic activity of a series of Ru-PNP pincer ligand complexes was studied in the direct amination of alcohols with ammonia. It turned out that all complexes of PNP ligands bearing a secondary amine showed no activity in this hydrogen-shuttling reaction sequence, while all complexes of homologous ligands bearing a tertiary amine gave active catalysts. Further comparative studies on catalysts bearing an acridine-based PNP pincer ligand and a PNP ligand of the Xantphos family provided valuable mechanistic insight that led to the design of a highly active catalyst. It appears that in the group of ligands studied here only ligands that do not form stable Ru-amido complexes are active alcohol amination catalysts.
Original languageEnglish
JournalCatalysis Science & Technology
Issue number15
Pages (from-to)3969-3976
Publication statusPublished - 2018
Externally publishedYes

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