Aberrant crypt foci in the colo-rectal mucosa as reliable markers of tumor development: with special reference to histomorphological and immunohistochemical characterization of aberrant crypt foci in rats

Inger Thorup

    Research output: Book/ReportPh.D. thesisResearch


    The aim of the present thesis has been to evaluate a recently
    developed short term
    in vivo
    model, the aberrant crypt foci
    bioassay (ACF), for its ability to predict the development of
    colo-rectal tumors. Based on the knowledge obtained during the
    last decade, it can be stated that no simple connection exists
    between occurrence of ACF (neither qualitatively nor quantita-
    tively) and later development of tumors. However, the literature
    has shown that part of the ACF show morphologic and genetic
    features characteristic for the tumorigenic process and a recent
    investigation indicate that all ACF belong to the same unity with
    basically the same chances for gradual progressing into tumors.
    It may be speculated that the progression depends on promo-
    tional conditions in the environment.
    Original languageEnglish
    PublisherNational Food Agency of Denmark
    Number of pages57
    Publication statusPublished - 1996

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