TY - JOUR
T1 - A role for the weak DnaA binding sites in bacterial replication origins
AU - Charbon, Godefroid
AU - Løbner-Olesen, Anders
PY - 2011/10
Y1 - 2011/10
N2 - DnaA initiates the chromosomal DNA replication in nearly all bacteria, and replication origins are characterized by binding sites for the DnaA protein (DnaA-boxes) along with an ‘AT-rich’ region. However, great variation in number, spatial organization and specificity of DnaA-boxes is observed between species. In the study by Taylor et al. (2011), new and unexpectedly weak DnaA-boxes were identified within the Caulobacter crescentus origin of replication (Cori). The position of weak and stronger DnaA-boxes follows a pattern seen in Escherichia coli oriC. This raises the possibility that bacterial origins might be more alike than previously thought.
AB - DnaA initiates the chromosomal DNA replication in nearly all bacteria, and replication origins are characterized by binding sites for the DnaA protein (DnaA-boxes) along with an ‘AT-rich’ region. However, great variation in number, spatial organization and specificity of DnaA-boxes is observed between species. In the study by Taylor et al. (2011), new and unexpectedly weak DnaA-boxes were identified within the Caulobacter crescentus origin of replication (Cori). The position of weak and stronger DnaA-boxes follows a pattern seen in Escherichia coli oriC. This raises the possibility that bacterial origins might be more alike than previously thought.
U2 - 10.1111/j.1365-2958.2011.07840.x
DO - 10.1111/j.1365-2958.2011.07840.x
M3 - Comment/debate
SN - 0950-382X
VL - 82
SP - 272
EP - 274
JO - Molecular Microbiology
JF - Molecular Microbiology
IS - 2
ER -