A Pneumococcal carriage study in danish pre-school children before the introduction of pneumococcal conjugate vaccination

Zitta B. Harboe, Hans Christian Slotved*, Helle B. Konradsen, Margit S. Kaltoft

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

Abstract

We present data on pneumococcal carriage before the introduction of the heptavalent-pneumococcal conjugated vaccine (PCV7) in Denmark. In the pre-PCV7 period, the incidence of invasive pneumococcal disease (IPD) among children younger than 5 years was approximately 25 per 100.000 population, with the highest incidence rates observed in children younger than 2 years of age. The study included 437 children aged 12-72 months attending day care centres (DCC) and was conducted during 48 months. In total, 56% (n=247) of children were pneumococcal carriers with the highest prevalence in children aged 12-23 months (69%), the proportion significantly declining with increasing age. PCV7 serotypes accounted for 33%, PCV10 for 34%, and PCV13 for 57% of all carried isolates. The proportion of serotypes included in the three conjugate vaccines was higher among IPD isolates compared to carrier isolates (range 35- 90%). We found that the frequency of carriage was high among Danish pre-school children attending DCC and serotypes were not frequently covered by PCV7 in the pre-PCV7 period.

Original languageEnglish
JournalOpen Microbiology Journal
Volume6
Issue number1
Pages (from-to)40-44
Number of pages5
ISSN1874-2858
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Children
  • Nasopharyngeal carriage
  • Serotypes
  • Streptococcus pneumoniae
  • Vaccine

Cite this