A multisubstrate deoxyribonucleoside kinase from plants

Anders R. Clausen; Lenart Girandon; Wolfgang Knecht; Sabeen Survery; Eric Andreasson; Birgitte Munch-Petersen; Jure Piskur

doi:10.1093/nass/nrn248

A multisubstrate deoxyribonucleoside kinase from plants

Anders R. Clausen, Lenart Girandon, Wolfgang Knecht, Sabeen Survery, Eric Andreasson, Birgitte Munch-Petersen, Jure Piskur

Research output: Contribution to journal › Conference article › Research

Abstract

Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.

Original language	English
Book series	Nucleic Acids Symposium Series
Pages (from-to)	489-490
Number of pages	2
ISSN	0261-3166
DOIs	https://doi.org/10.1093/nass/nrn248
Publication status	Published - 2008
Event	Joint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry - Tokyo, Japan Duration: 8 Sept 2008 → 12 Sept 2008

Conference

Conference	Joint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry
Country/Territory	Japan
City	Tokyo
Period	08/09/2008 → 12/09/2008

Keywords

deoxyribonucleoside kinase
Arabidopsis

Link to document

10.1093/nass/nrn248

Cite this

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title = "A multisubstrate deoxyribonucleoside kinase from plants",

abstract = "Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.",

keywords = "plants, deoxyribonucleoside kinase, Arabidopsis",

author = "Clausen, {Anders R.} and Lenart Girandon and Wolfgang Knecht and Sabeen Survery and Eric Andreasson and Birgitte Munch-Petersen and Jure Piskur",

note = "Volumne: 52; Joint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry ; Conference date: 08-09-2008 Through 12-09-2008",

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doi = "10.1093/nass/nrn248",

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T1 - A multisubstrate deoxyribonucleoside kinase from plants

AU - Clausen, Anders R.

AU - Girandon, Lenart

AU - Knecht, Wolfgang

AU - Survery, Sabeen

AU - Andreasson, Eric

AU - Munch-Petersen, Birgitte

AU - Piskur, Jure

N1 - Volumne: 52

PY - 2008

Y1 - 2008

N2 - Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.

AB - Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.

KW - plants

KW - deoxyribonucleoside kinase

KW - Arabidopsis

U2 - 10.1093/nass/nrn248

DO - 10.1093/nass/nrn248

M3 - Conference article

SN - 0261-3166

SP - 489

EP - 490

JO - Nucleic Acids Symposium Series

JF - Nucleic Acids Symposium Series

T2 - Joint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry

Y2 - 8 September 2008 through 12 September 2008

ER -