A multisubstrate deoxyribonucleoside kinase from plants

Anders R. Clausen, Lenart Girandon, Wolfgang Knecht, Sabeen Survery, Eric Andreasson, Birgitte Munch-Petersen, Jure Piskur

    Research output: Contribution to journalConference articleResearch

    Abstract

    Deoxyribonucleoside kinases catalyze the rate limiting step during the salvage of deoxyribonucleosides and convert them into the corresponding monophosphate compounds. We have identified and characterized a unique multisubstrate deoxyribonucleoside kinase from plants. The phylogenetic relationship and biochemical properties suggest that this deoxyribonucleoside kinase represents a living fossil resembling the progenitor of the modern animal deoxycytidine, deoxyguanosine and thymidine 2 kinases. The broad substrate specificity makes this enzyme an interesting candidate to be evaluated as a suicide gene in anti-cancer therapy.
    Original languageEnglish
    Book seriesNucleic Acids Symposium Series
    Pages (from-to)489-490
    Number of pages2
    ISSN0261-3166
    DOIs
    Publication statusPublished - 2008
    EventJoint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry - Tokyo, Japan
    Duration: 8 Sep 200812 Sep 2008

    Conference

    ConferenceJoint symposium of the 18th international roundtable on nucleosides, nucleotides and nucleic acids and the 35th international symposium on nucleic acids chemistry
    CountryJapan
    CityTokyo
    Period08/09/200812/09/2008

    Keywords

    • deoxyribonucleoside kinase
    • Arabidopsis

    Cite this

    Clausen, A. R., Girandon, L., Knecht, W., Survery, S., Andreasson, E., Munch-Petersen, B., & Piskur, J. (2008). A multisubstrate deoxyribonucleoside kinase from plants. Nucleic Acids Symposium Series, 489-490. https://doi.org/10.1093/nass/nrn248