A mathematical model of human thymidine kinase 2 activity

Tom Radivoyevitch, Birgitte Munch-Petersen, Liya Wang, Staffan Eriksson

    Research output: Contribution to journalJournal articlepeer-review

    Abstract

    _ The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of ∼0.5 (apparent negative cooperativity) for dT and ∼1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.
    Original languageEnglish
    JournalNucleosides, Nucleotides and Nucleic Acids
    Volume30
    Issue number3
    Pages (from-to)203-209
    Number of pages7
    ISSN1525-7770
    DOIs
    Publication statusPublished - 2011

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