A glycosyltransferase inhibitor from a molecular fragment library simultaneously interferes with metal ion and substrate binding

Rene Jørgensen; Lena Lisbeth Grimm; Nora Sindhuwinata; Thomas Peters; Monica M. Palcic

doi:10.1002/anie.201108345

A glycosyltransferase inhibitor from a molecular fragment library simultaneously interferes with metal ion and substrate binding

Rene Jørgensen^*, Lena Lisbeth Grimm, Nora Sindhuwinata, Thomas Peters, Monica M. Palcic

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A fragmented approach: 3-Phenyl-5-piperazino-1,2,4-thiadiazole (designated "compound382" in the Ro5 Maybridge Fragment Library, see scheme) is demonstrated to be an effective inhibitor of human blood group glycosyltransferaseB. The compound interferes with both acceptor and donor binding and also displaces the Mn ²⁺ ion in the binding pocket.

Original language	English
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	17
Pages (from-to)	4171-4175
Number of pages	5
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.201108345
Publication status	Published - 23 Apr 2012
Externally published	Yes

Keywords

glycosyltransferases
NMR spectroscopy
surface plasmon resonance
X-ray crystallography

Link to document

10.1002/anie.201108345

Cite this

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title = "A glycosyltransferase inhibitor from a molecular fragment library simultaneously interferes with metal ion and substrate binding",

abstract = "A fragmented approach: 3-Phenyl-5-piperazino-1,2,4-thiadiazole (designated {"}compound382{"} in the Ro5 Maybridge Fragment Library, see scheme) is demonstrated to be an effective inhibitor of human blood group glycosyltransferaseB. The compound interferes with both acceptor and donor binding and also displaces the Mn 2+ ion in the binding pocket.",

keywords = "glycosyltransferases, NMR spectroscopy, surface plasmon resonance, X-ray crystallography",

author = "Rene J{\o}rgensen and Grimm, {Lena Lisbeth} and Nora Sindhuwinata and Thomas Peters and Palcic, {Monica M.}",

year = "2012",

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language = "English",

volume = "51",

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A glycosyltransferase inhibitor from a molecular fragment library simultaneously interferes with metal ion and substrate binding. / Jørgensen, Rene; Grimm, Lena Lisbeth; Sindhuwinata, Nora et al.
In: Angewandte Chemie - International Edition, Vol. 51, No. 17, 23.04.2012, p. 4171-4175.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - A glycosyltransferase inhibitor from a molecular fragment library simultaneously interferes with metal ion and substrate binding

AU - Jørgensen, Rene

AU - Grimm, Lena Lisbeth

AU - Sindhuwinata, Nora

AU - Peters, Thomas

AU - Palcic, Monica M.

PY - 2012/4/23

Y1 - 2012/4/23

N2 - A fragmented approach: 3-Phenyl-5-piperazino-1,2,4-thiadiazole (designated "compound382" in the Ro5 Maybridge Fragment Library, see scheme) is demonstrated to be an effective inhibitor of human blood group glycosyltransferaseB. The compound interferes with both acceptor and donor binding and also displaces the Mn 2+ ion in the binding pocket.

AB - A fragmented approach: 3-Phenyl-5-piperazino-1,2,4-thiadiazole (designated "compound382" in the Ro5 Maybridge Fragment Library, see scheme) is demonstrated to be an effective inhibitor of human blood group glycosyltransferaseB. The compound interferes with both acceptor and donor binding and also displaces the Mn 2+ ion in the binding pocket.

KW - glycosyltransferases

KW - NMR spectroscopy

KW - surface plasmon resonance

KW - X-ray crystallography

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U2 - 10.1002/anie.201108345

DO - 10.1002/anie.201108345

M3 - Journal article

C2 - 22407594

AN - SCOPUS:84859982558

SN - 1433-7851

VL - 51

SP - 4171

EP - 4175

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 17

ER -

A glycosyltransferase inhibitor from a molecular fragment library simultaneously interferes with metal ion and substrate binding

Abstract

Keywords

Link to document

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