A Functional cra Gene Is Required forSalmonella enterica Serovar Typhimurium Virulence in BALB/c Mice

James H Allen; Maryjane Utley; Han van den Bosch; Piet Nuijten; Maarten Witvliet; Beth A McCormick; Karen A Krogfelt; Tine Rask Licht; Derek Brown; Michael Mauel; Mary P Leatham; David C Laux; Paul S Cohen

A Functional cra Gene Is Required forSalmonella enterica Serovar Typhimurium Virulence in BALB/c Mice

James H Allen, Maryjane Utley, Han van den Bosch, Piet Nuijten, Maarten Witvliet, Beth A McCormick, Karen A Krogfelt, Tine Rask Licht, Derek Brown, Michael Mauel, Mary P Leatham, David C Laux, Paul S Cohen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad−, is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129–134, 1998). Here, evidence is presented that the mutation in SR-11 Fad− that renders the strain avirulent is in the cra gene, which encodes the Cra protein, a regulator of central carbon metabolism.

Original language	Undefined/Unknown
Journal	Infection and Immunity
Volume	68
Issue number	6
Pages (from-to)	3772-3775
Number of pages	4
ISSN	0019-9567
Publication status	Published - 2000
Externally published	Yes

Cite this

@article{bdfbc63835e046c189c291aab510007c,

title = "A Functional cra Gene Is Required forSalmonella enterica Serovar Typhimurium Virulence in BALB/c Mice",

abstract = "A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad−, is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129–134, 1998). Here, evidence is presented that the mutation in SR-11 Fad− that renders the strain avirulent is in the cra gene, which encodes the Cra protein, a regulator of central carbon metabolism.",

author = "Allen, {James H} and Maryjane Utley and {van den Bosch}, Han and Piet Nuijten and Maarten Witvliet and McCormick, {Beth A} and Krogfelt, {Karen A} and Licht, {Tine Rask} and Derek Brown and Michael Mauel and Leatham, {Mary P} and Laux, {David C} and Cohen, {Paul S}",

year = "2000",

language = "Udefineret/Ukendt",

volume = "68",

pages = "3772--3775",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "6",

}

TY - JOUR

T1 - A Functional cra Gene Is Required forSalmonella enterica Serovar Typhimurium Virulence in BALB/c Mice

AU - Allen, James H

AU - Utley, Maryjane

AU - van den Bosch, Han

AU - Nuijten, Piet

AU - Witvliet, Maarten

AU - McCormick, Beth A

AU - Krogfelt, Karen A

AU - Licht, Tine Rask

AU - Brown, Derek

AU - Mauel, Michael

AU - Leatham, Mary P

AU - Laux, David C

AU - Cohen, Paul S

PY - 2000

Y1 - 2000

N2 - A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad−, is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129–134, 1998). Here, evidence is presented that the mutation in SR-11 Fad− that renders the strain avirulent is in the cra gene, which encodes the Cra protein, a regulator of central carbon metabolism.

AB - A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad−, is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129–134, 1998). Here, evidence is presented that the mutation in SR-11 Fad− that renders the strain avirulent is in the cra gene, which encodes the Cra protein, a regulator of central carbon metabolism.

M3 - Tidsskriftartikel

SN - 0019-9567

VL - 68

SP - 3772

EP - 3775

JO - Infection and Immunity

JF - Infection and Immunity

IS - 6

ER -