A Functional cra Gene Is Required forSalmonella enterica Serovar Typhimurium Virulence in BALB/c Mice

James H Allen, Maryjane Utley, Han van den Bosch, Piet Nuijten, Maarten Witvliet, Beth A McCormick, Karen A Krogfelt, Tine Rask Licht, Derek Brown, Michael Mauel, Mary P Leatham, David C Laux, Paul S Cohen

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A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad−, is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129–134, 1998). Here, evidence is presented that the mutation in SR-11 Fad− that renders the strain avirulent is in the cra gene, which encodes the Cra protein, a regulator of central carbon metabolism.
Original languageUndefined/Unknown
JournalInfection and Immunity
Issue number6
Pages (from-to)3772-3775
Number of pages4
Publication statusPublished - 2000
Externally publishedYes

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