@article{f53695b913034a108eaf900450d60ecd,
title = "1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice",
abstract = "Adult-type hypolactasia is a genetic condition making approximately one half of the human population intolerant to milk because of abdominal symptoms. The cause is a post-weaning down-regulation of the intestinal-specific enzyme lactase-phlorizin hydrolase (LPH) reducing the intestinal capacity to hydrolyze lactose. We here demonstrate that the stretch -17 to -994 in the pig LPH-promoter carries cis-elements which direct a small intestinal-specific expression and a post-weaning decline of a linked rabbit β-globin gene. These data demonstrate that the post-weaning decline of LPH is mainly due to a transcriptional down-regulation.",
keywords = "Enterocyte, Hypolactasia, Lactase-phlorizin hydrolase, Lactose intolerance, Small intestine, Tissue specificity, Enterocyte, Hypolactasia, Lactase-phlorizin hydrolase, Lactose intolerance, Small intestine, Tissue specificity",
author = "Troelsen, {Jesper T.} and Anja Mehlum and J{\o}rgen Olsen and Nikolaj Spodsberg and Hansen, {Gert H.} and Hans Prydz and Ove Nor{\'e}n and Hans Sj{\"o}str{\"o}m",
note = "Funding Information: AcknowledgemenWtse: t hankA netteM . Kennebo,M ona Nilsson and Jette Meller for excellentt echnicala ssistancea, nd we wish to thank HanneL ykke Hansena nd Erik Dabelsteenfo r the helpw ith the prep-arationo f the tissuef or in situ hybridizationT. his work was supported by grantsf rom The NorwegianC ancer Society,T he NorwegianR e-searchC ouncil (NAVF), The Danish Medical ResearchC ouncil and The LundbeckF oundation.T his projectw asa parto f a programu nder BiomembraneR esearchC enter,A arhus University.",
year = "1994",
month = apr,
day = "11",
doi = "10.1016/0014-5793(94)80519-9",
language = "English",
volume = "342",
pages = "291--296",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd.",
number = "3",
}