Long-term Impact of Childhood Vaccination Programs: Using Historical data to Understand Modern Disease Patterns

Project: Research

Project Details


Childhood vaccination programs are often presented as one of the main reasons for the historic decline in infectious disease mortality. However, this subject has mainly been investigated in contemporary settings without the long view needed to gain a complete understanding of disease patterns after decades of vaccine use.

Our strategy is to leverage Denmark’s rich historical health and vital statistics data to quantitatively address current population-level questions about childhood vaccination: How do vaccines affect the ecology and impact of epidemic diseases over several decades? Were measles epidemics truly associated with measurable increases in other causes of pediatric mortality? What fraction of the 20th century mortality reduction in European countries can be attributed to vaccines? Why have epidemic diseases such as measles, mumps and pertussis, once well-controlled by vaccines, re-emerged now?
Effective start/end date01/06/201830/11/2020

Research Output

  • 2 Poster
  • 1 Journal article
  • 1 Comment/debate

Influenza in Greenland 1914 - 1921: Untold Stories and Diverging Patterns

Ingholt, M. M., van Wijhe, M., Perner, M. L. & Simonsen, L., 31 Aug 2019.

Research output: Contribution to conferencePosterResearch

Open Access

Integrated vaccine economics for countries transitioning from Gavi support

van Wijhe, M. & Simonsen, L., 1 Dec 2019, In : The Lancet Global Health. 7, 12, p. E1591-E1592 2 p.

Research output: Contribution to journalComment/debateResearchpeer-review

Open Access
Open Access

Loose Ends in the Epidemiology of the 1918 Pandemic: Explaining the Extreme Mortality Risk in Young Adults

Wijhe, M. V., Ingholt, M. M., Andreasen, V. & Simonsen, L., 6 Sep 2018, In : American Journal of Epidemiology. 187, 12, p. 2503–2510 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review


  • 1 Organisation and participation in conference

Options X

Maarten van Wijhe (Participant)

28 Aug 20191 Sep 2019

Activity: Participating in or organising an eventOrganisation and participation in conference

Press / Media

Disease X: Which Plague is Coming Next?

Lone Simonsen & Maarten van Wijhe


1 Media contribution

Press/Media: Press / Media

Forsker Maarten van Wijhe jagter epidemier gennem computerdata

Maarten van Wijhe


1 item of Media coverage

Press/Media: Press / Media