Peter Westh

Search results

• 2022

  Analysis of fungal high-mannose structures using CAZymes

  Kołaczkowski, B. M., Jørgensen, C. I., Spodsberg, N., Stringer, M. A., Supekar, N. T., Azadi, P., Westh, P., Krogh, K. B. R. M. & Jensen, K., 1 Apr 2022, In: Glycobiology. 32, 4, p. 304-313 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Sabatier Principle for Rationalizing Enzymatic Hydrolysis of a Synthetic Polyester

  Arnling Bååth, J., Jensen, K., Borch, K., Westh, P. & Kari, J., 23 May 2022, In: Journal of American Chemical Society Au. 2, 5, p. 1223–1231 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Virtual Bioprospecting of Interfacial Enzymes: Relating Sequence and Kinetics

  Schaller, K. S., Molina, G. A., Kari, J., Schiano-di-Cola, C., Sørensen, T. H., Borch, K., Peters, G. H. & Westh, P., 17 Jun 2022, In: ACS Catalysis. 12, 12, p. 7427–7435 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2021

  A comparative biochemical investigation of the impeding effect of C1-oxidizing LPMOs on cellobiohydrolases

  Keller, M. B., Badino, S. F., Røjel, N., Sørensen, T. H., Kari, J., McBrayer, B., Borch, K., Blossom, B. M. & Westh, P., 1 Jan 2021, In: Journal of Biological Chemistry. 296, 100504.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

• Computing Cellulase Kinetics with a Two-Domain Linear Interaction Energy Approach

  Schaller, K. S., Kari, J., Molina, G. A., Tidemand, K. D., Borch, K., Peters, G. H. J. & Westh, P., 19 Jan 2021, In: ACS Omega. 6, 2, p. 1547-1555 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

• Physical constraints and functional plasticity of cellulases

  Kari, J., Molina, G. A., Schaller, K. S., Schiano-di-Cola, C., Christensen, S. J., Badino, S. F., Sørensen, T. H., Røjel, N. S., Keller, M. B., Sørensen, N. R., Kolaczkowski, B., Olsen, J. P., Krogh, K. B. R. M., Jensen, K., Cavaleiro, A. M., Peters, G. H. J., Spodsberg, N., Borch, K. & Westh, P., 12 Jun 2021, In: Nature Communications. 12, 1, 3847.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File
• 2020

  Activity of fungal β-glucosidases on cellulose

  Keller, M. B., Sørensen, T. H., Krogh, K. B. R. M., Wogulis, M., Borch, K. & Westh, P., 10 Jul 2020, In: Biotechnology for Biofuels. 13, 1, 121.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Molecular recognition in the product site of cellobiohydrolase Cel7A regulates processive step length

  Olsen, J. P., Kari, J., Windahl, M. S., Borch, K. & Westh, P., 8 Jan 2020, In: Biochemical Journal. 477, 1, p. 99-110 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

• pH profiles of cellulases depend on the substrate and architecture of the binding region

  Røjel, N. S., Kari, J., Sørensen, T. H., Borch, K. & Westh, P., Jan 2020, In: Biotechnology and Bioengineering (Print). 117, 2, p. 382–391 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Removal of N-linked glycans in cellobiohydrolase Cel7A from Trichoderma reesei reveals higher activity and binding affinity on crystalline cellulose

  Kolaczkowski, B., Schaller, K. S., Sørensen, T. H., Peters, G. H. J., Jensen, K., Krogh, K. B. R. M. & Westh, P., 6 Aug 2020, In: Biotechnology for Biofuels. 13, 136.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

• Selective pressure on an interfacial enzyme: Functional roles of a highly conserved asparagine residue in a cellulase

  Sørensen, T. H., Badino, S. F., Windahl, M. S., Røjel, N. S., McBrayer, B., Borch, K. & Westh, P., Mar 2020, In: B B A - Proteins and Proteomics. 1868, 3, 140359.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Structural and biochemical characterization of a family 7 highly thermostable endoglucanase from the fungus Rasamsonia emersonii

  Cola, C. S. D., Kolaczkowski, B., Sørensen, T. H., Christensen, S. J., Cavaleiro, A. M., Windahl, M. S., Borch, K., Morth, J. P. & Westh, P., 2020, In: F E B S Journal. 287, 12, p. 2577-2596 20 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Substrate binding in the processive cellulase Cel7A: Transition state of complexation and roles of conserved tryptophan residues

  Røjel, N. S., Kari, J., Sørensen, T. H., Badino, S. F., Morth, J. P., Schaller, K., Cavaleiro, A. M., Borch, K. & Westh, P., 2020, In: Journal of Biological Chemistry. 295, 6, p. 1454 –1463 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  File
• 2019

  A practical approach to steady-state kinetic analysis of cellulases acting on their natural insoluble substrate

  Kari, J., Christensen, S. J., Wienecke Andersen, M., Sellés Baiget, S., Borch, K. & Westh, P., 2019, In: Analytical Biochemistry. 2019, 586, 113411.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Functional analysis of chimeric TrCel6A enzymes with different carbohydrate binding modules

  Christensen, S. J., Badino, S. F., Cavaleiro, A. M., Borch, K. & Westh, P., 2019, In: Protein Engineering Design and Selection . 32, 9, p. 401-409 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Systematic deletions in the cellobiohydrolase (CBH) Cel7A from the fungus Trichoderma reesei reveal flexible loops critical for CBH activity

  Cola, C. S. D., Røjel, N. S., Jensen, K., Kari, J., Sørensen, T. H., Borch, K. & Westh, P., 2019, In: Journal of Biological Chemistry. 294, 6, p. 1807-1815 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access
• 2018

  Correlation of structure, function and protein dynamics in GH7 cellobiohydrolases from Trichoderma atroviride, T. reesei and T. harzianum

  Borisova, A. S., Eneyskaya, E. V., Jana, S., Badino, S. F., Kari, J., Amore, A., Karlsson, M., Hansson, H., Sandgren, M., Himmel, M. E., Westh, P., Payne, C. M., Kulminskaya, A. A. & Ståhlberg, J., 2018, In: Biotechnology for Biofuels. 11, 5, 22 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Effect of alginate size, mannuronic/guluronic acid content and pH on particle size, thermodynamics and composition of complexes with beta-lactoglobulin

  Stender, E. G. P., Khan, S., Ipsen, R., Madsen, F., Hägglund, P., Abou Hachem, M., Almdal, K., Westh, P. & Svensson, B., Jan 2018, In: Food Hydrocolloids. 75, p. 157-163 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Isothermal Titration Calorimetry Study of Brine–Oil–Rock Interactions

  Mora, J. E. C., Westh, P. & Søgaard, E. G., 2018, In: Energy & Fuels. 32, 7, p. 7338-7346 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Michaelis - Menten equation for degradation of insoluble substrate

  Andersen, M., Kari, J., Borch, K. & Westh, P., 2018, In: Mathematical Biosciences. 296, p. 93-97 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Rate‐limiting step and substrate accessibility of cellobiohydrolase Cel6A from Trichoderma reesei

  Christensen, S. J., Kari, J., Badino, S. F., Borch, K. & Westh, P., 17 Oct 2018, In: F E B S Journal. 285, 23, p. 4482-4493 12 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Sabatier Principle for Interfacial (Heterogeneous) Enzyme Catalysis

  Kari, J., Olsen, J. P., Jensen, K., Badino, S. F., Krogh, K. B. R. M., Borch, K. & Westh, P., 2018, In: ACS Catalysis. 8, 12, p. 11966-11972

  Research output: Contribution to journal › Journal article › Research › peer-review

• Thermoactivation of a cellobiohydrolase

  Westh, P., Borch, K., Sørensen, T. H., Tokin, R., Kari, J., Badino, S. F., Cavaleiro, M. A., Røjel, N. S., Christensen, S. J., Vesterager, C. S. & Cola, C. S. D., Jan 2018, In: Biotechnology and Bioengineering (Print). 115, 4, p. 831-838 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2017

  An Inverse Michaelis–Menten Approach for Interfacial Enzyme Kinetics

  Kari, J., Andersen, M., Borch, K. & Westh, P., 2017, In: ACS Catalysis. 7, 7, p. 4904–4914 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Anomeric Selectivity and Product Profile of a Processive Cellulase

  Kari, J., Kont, R., Borch, K., Buskov, S., Olsen, J. P., Cruyz-Bagger, N., Väljamäe, P. & Westh, P., 2017, In: Biochemistry. 56, 1, p. 167-178 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• A quenched-flow system for measuring heterogeneous enzyme kinetics with sub-second time resolution

  Olsen, J. P., Kari, J., Borch, K. & Westh, P., 2017, In: Enzyme and Microbial Technology. 105, p. 45-50 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Direct kinetic comparison of the two cellobiohydrolases Cel6A and Cel7A from Hypocrea jecorina

  Badino, S. F., Kari, J., Christensen, S. J., Borch, K. & Westh, P., Dec 2017, In: B B A - Proteins and Proteomics. 1865, 12, p. 1739-1745 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Endo/exo-synergism of cellulases increases with substrate conversion

  Olsen, J. P., Borch, K. & Westh, P., 2017, In: Biotechnology and Bioengineering. 114, 3, p. 696-700

  Research output: Contribution to journal › Journal article › Research › peer-review

• Exo-exo synergy between Cel6A and Cel7A from Hypocrea jecorina: Role of carbohydrate binding module and the endo-lytic character of the enzymes

  Badino, S. F., Christensen, S. J., Kari, J., Windahl, M. S., Hvidt, S., Borch, K. & Westh, P., 2017, In: Biotechnology and Bioengineering (Print). 114, 8, p. 1639–1647 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Loop variants of the thermophile Rasamsonia emersonii Cel7A with improved activity against cellulose

  Sørensen, T. H., Skovbo Windahl, M., McBrayer, B., Kari, J., Olsen, J. P., Borch, K. & Westh, P., 2017, In: Biotechnology and Bioengineering. 114, 1, p. 53-62 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• The influence of different linker modifications on the catalytic activity and cellulose affinity of cellobiohydrolase Cel7A from Hypocrea jecorina

  Badino, S. F., Kim Bathke, J., Sørensen, T. H., Windahl, M. S., Jensen, K., Peters, G. H., Borch, K. & Westh, P., 25 Jul 2017, In: Protein Engineering Design and Selection . 30, 7, p. 495-501 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review
• 2016

  A heuristic model to quantify the impact of excess cyclodextrin on oral drug absorption from aqueous solution

  Olesen, N. E., Westh, P. & Holm, R., 2016, In: European Journal of Pharmaceutics and Biopharmaceutics. 102, p. 142-151

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Calorimetric assays for heterogeneous enzyme catalysis: Hydrolysis of cellulose and biomass

  Westh, P. & Borch, K., 2016, Biocalorimetry: Foundations and contempory approaches. Bastos, M. (ed.). Boca Raton: CRC Press, p. 381-394

  Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

• Displacement of Drugs From Cyclodextrin Complexes by Bile Salts: A Suggestion of an Intestinal Drug-Solubilizing Capacity From an In Vitro Model

  Olesen, N. E., Westh, P. & Holm, R., 2016, In: Journal of Pharmaceutical Sciences. 105, 9, p. 2640-2647

  Research output: Contribution to journal › Journal article › Research › peer-review

• Effect of cyclodextrin concentration on the oral bioavailability of danazol and cinnarizine in rats

  Holm, R., Olesen, N. E., Andersen Hartvig, R., Jørgensen, E. B., Larsen, D. B. & Westh, P., 2016, In: European Journal of Pharmaceutics and Biopharmaceutics. 101, p. 9-14

  Research output: Contribution to journal › Journal article › Research › peer-review

• Hydration Differences Explain the Large Variations in the Complexation Thermodynamics of Modified γ-Cyclodextrins with Bile Salts

  Køhler, J., Schönbeck, J. C. S., Westh, P. & Holm, R., 2016, In: The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 120, 3, p. 396–405

  Research output: Contribution to journal › Journal article › Research › peer-review

• Inter-domain synergism is required for efficient feeding of cellulose chain into active site of cellobiohydrolase Cel7A

  Kont, R., Kari, J., Borch, K., Westh, P. & Väljamäe, P., 2016, In: Journal of Biological Chemistry. 291, p. 26013-26023

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

• Interrelationships between cellulase activity and cellulose particle morphology

  Olsen, J. P., Donohoe, B. S., Borch, K., Westh, P. & Resch, M. G., Aug 2016, In: Cellulose. 23, 4, p. 2349-2361

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Mechanism of product inhibition for cellobiohydrolase Cel7A during hydrolysis of insoluble cellulose

  Olsen, J. P., Alasepp, K., Kari, J., Cruys-Bagger, N., Borch, K. & Westh, P., 2016, In: Biotechnology and Bioengineering. 113, 6, p. 1178-1186 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• Rate of Threading a Cellulose Chain into the Binding Tunnel of a Cellulase

  Cruys-Bagger, N., Alasepp, K., Andersen, M., Ottesen, J. T., Borch, K. & Westh, P., 2016, In: The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 120, 25, 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

• The effect of 2,2,2-trifluoroethanol on water studied by using third derivatives of Gibbs energy, G

  Ohgi, H., Imamura, H., Yonenaga, K., Morita, T., Nishikawa, K., Westh, P. & Koga, Y., 2016, In: Journal of Molecular Liquids. 224A, p. 401-407

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Thermodynamic investigation of the interaction between cyclodextrins and preservatives: Application and verification in a mathematical model to determine the needed preservative surplus in aqueous cyclodextrin formulations

  Holm, R., Olesen, N. E., Alexandersen, S. D., Dahlgaard, B. N., Westh, P. & Mu, H., 2016, In: European Journal of Pharmaceutical Sciences. 87, p. 22-29

  Research output: Contribution to journal › Journal article › Research › peer-review

• WO/2016/13867 CELLOBIOHYDROLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME

  McBrayer, B., Skovbo Windahl, M., Westh, P., Badino, S. F. & Borch, K., 1 Sept 2016, Priority date 1 Sept 2016, Priority No. 138167

  Research output: Patent

• 2015

  Determination of thermodynamic potentials and the aggregation number for micelles with the mass-action model by isothermal titration calorimetry: A case study on bile salts

  Olesen, N. E., Westh, P. & Holm, R., 2015, In: Journal of Colloid and Interface Science. 453, p. 79-89

  Research output: Contribution to journal › Journal article › Research › peer-review

• Effect of mutations on the thermostability of Aspergillus aculeatus β-1, 4-galactanase

  Terpenholt, S., De Maria, L., Olsson, M. H. M., Christensen, L. H., Skjøt, M., Westh, P., Jensen, J. H. & Lo Leggio, L., 2015, In: Computational and Structural Biotechnology Journal. 2015, 13, p. 256-264

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Effects of constituent ions of a phosphonium-based ionic liquid on molecular organization of H2O as probed by 1-propanol: tetrabutylphosphonium and trifluoroacetate ions

  Morita, T., Miki, K., Ayako, N., Ohgi, H. & Westh, P., 2015, In: Physical Chemistry Chemical Physics. 17, p. 22170-8

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Free energy diagram for the heterogeneous enzymatic hydrolysis of glycosidic bonds in cellulose

  Westh, P., Cruys-Bagger, N., Sørensen, T. H. & Borch, K., 2015, In: Journal of Biological Chemistry. 290, 36, p. 22203-22211

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Probing substrate interactions in the active tunnel of a catalytically deficient cellobiohydrolase (Cel7)

  Westh, P., Colussi, F., Sørensen, T. H., Alasepp, K., Kari, J., Cruys-Bagger, N., Windahl, M. S., Olsen, J. P. & Borch, K., 23 Jan 2015, In: Journal of Biological Chemistry. 290, 4, p. 2444-2454

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Temperature effects on kinetic parameters and substrate affinity of Cel7A cellobiohydrolases

  Sørensen, T. H., Cruys-Bagger, N., Windahl, M. S., Badino, S. F. & Westh, P., 2015, In: Journal of Biological Chemistry. 290, p. 22193-22202

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

• Third derivative thermodynamic quantities of aqueous tetrahydrofuran at 25 degrees C

  Westh, P., Yoshida, K., Inaba, A., Nakano, M. & Koga, Y., Feb 2015, In: Journal of Molecular Liquids. 202, p. 40-45

  Research output: Contribution to journal › Journal article › Research › peer-review