Lotte Jelsbak

MSc & PhD

  • Universitetsvej 1, 28A.1

    DK-4000 Roskilde

    Denmark

20042020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research

My research aims to find new ways to prevent and cure important bacterial infections. To this end, I study the molecular mechanisms of host-pathogen interactions and host-adaptation of bacterial infections to identify novel virulence mechanism and develop these into suitable antimicrobial targets. I am particularly interested in elucidating the molecular mechanisms of the link between pathogen in vivo metabolism and virulence, and how metabolic status affects disease progression, with a potential for identifying novel pathogen-specific targets for treatment of bacterial infections. To this end, I am employing the human pathogen Salmonella Typhimurium as a model for both intestinal and systemic infections of a mouse model. In relation to this, I have in recent studies, characterized the essential metabolic capacity of Salmonella for successful infections and identified several metabolic pathways that are essential for virulence of Salmonella. In a current study, I have isolated a strain of Salmonella that has adapted to the systemic environment during persistent infections. Using Whole Genome Sequencing, I have identified novel metabolic enzymes that are essential for chronic Salmonella infections.

 

Research

Inhibition of Salmonella Biofilm Formation.

Publication network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

  • 22 Journal article
  • 4 Conference abstract for conference
  • 1 Review

Polyamine depletion has global effects on stress and virulence gene expression and affects HilA translation in Salmonella enterica serovar typhimurium

Guerra, P. R., Liu, G., Lemire, S., Nawrocki, A., Kudirkiene, E., Møller-Jensen, J., Olsen, J. E. & Jelsbak, L., 2020, In : Research in Microbiology.

Research output: Contribution to journalJournal articleResearchpeer-review

Resistance to piperacillin/tazobactam in Escherichia coli resulting from extensive IS26-associated gene amplification of blaTEM-1

Hansen, K. H., Andreasen, M. R., Pedersen, M. S., Westh, H., Jelsbak, L. & Schønning, K., 2019, In : Journal of Antimicrobial Chemotherapy. 74, 11, p. 3179-3183

Research output: Contribution to journalJournal articleResearchpeer-review

The SPI-19 encoded type-six secretion-systems (T6SS) of Salmonella enterica serovars Gallinarum and Dublin play different roles during infection

Schroll, C., Huang, K., Ahmed, S., Kristensen, B. M., Pors, S. E., Jelsbak, L., Lemire, S., Thomsen, L. E., Christensen, J. P., Jensen, P. R. & Olsen, J. E., 2019, In : Veterinary Microbiology. 230, p. 23-31 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Extensive IS26 mediated gene duplication of blaTEM-1 as a cause of resistance to piperacillin-tazobactam in Escherichia coli

Jelsbak, L., Andreasen, M. R., Hansen, K. H., Pedersen, M. S., Schønning, K., Westh, H., Hansen, T. A. & Pedersen, M., 2018.

Research output: Contribution to conferenceConference abstract for conferenceResearch

Projects

Press / Media

Donation

Lotte Jelsbak

06/01/2020

1 item of Media coverage

Press/Media: Press / Media

RUC får 1,6 mio. kr. til forskning i salmonella fra Novo Nordisk Fonden

Lotte Jelsbak

19/12/2019

1 item of Media coverage

Press/Media: Press / Media