Research Output per year
Personal profile
Research
My research aims to find new ways to prevent and cure important bacterial infections. To this end, I study the molecular mechanisms of host-pathogen interactions and host-adaptation of bacterial infections to identify novel virulence mechanism and develop these into suitable antimicrobial targets. I am particularly interested in elucidating the molecular mechanisms of the link between pathogen in vivo metabolism and virulence, and how metabolic status affects disease progression, with a potential for identifying novel pathogen-specific targets for treatment of bacterial infections. To this end, I am employing the human pathogen Salmonella Typhimurium as a model for both intestinal and systemic infections of a mouse model. In relation to this, I have in recent studies, characterized the essential metabolic capacity of Salmonella for successful infections and identified several metabolic pathways that are essential for virulence of Salmonella. In a current study, I have isolated a strain of Salmonella that has adapted to the systemic environment during persistent infections. Using Whole Genome Sequencing, I have identified novel metabolic enzymes that are essential for chronic Salmonella infections.
Research
Inhibition of Salmonella Biofilm Formation.
Publication network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output
Polyamine depletion has global effects on stress and virulence gene expression and affects HilA translation in Salmonella enterica serovar typhimurium
Guerra, P. R., Liu, G., Lemire, S., Nawrocki, A., Kudirkiene, E., Møller-Jensen, J., Olsen, J. E. & Jelsbak, L., 2020, In : Research in Microbiology.Research output: Contribution to journal › Journal article › Research › peer-review
Resistance to piperacillin/tazobactam in Escherichia coli resulting from extensive IS26-associated gene amplification of blaTEM-1
Hansen, K. H., Andreasen, M. R., Pedersen, M. S., Westh, H., Jelsbak, L. & Schønning, K., 2019, In : Journal of Antimicrobial Chemotherapy. 74, 11, p. 3179-3183Research output: Contribution to journal › Journal article › Research › peer-review
The SPI-19 encoded type-six secretion-systems (T6SS) of Salmonella enterica serovars Gallinarum and Dublin play different roles during infection
Schroll, C., Huang, K., Ahmed, S., Kristensen, B. M., Pors, S. E., Jelsbak, L., Lemire, S., Thomsen, L. E., Christensen, J. P., Jensen, P. R. & Olsen, J. E., 2019, In : Veterinary Microbiology. 230, p. 23-31 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Extensive IS26 mediated gene duplication of blaTEM-1 as a cause of resistance to piperacillin-tazobactam in Escherichia coli
Jelsbak, L., Andreasen, M. R., Hansen, K. H., Pedersen, M. S., Schønning, K., Westh, H., Hansen, T. A. & Pedersen, M., 2018.Research output: Contribution to conference › Conference abstract for conference › Research
Health risk associated with plastic debris on the Island of Zanzibar: – Importance of associated pathogenic bacteria and implications for local communities
Syberg, K., Buur, L., Jelsbak, L. & Simonsen, L., 2018.Research output: Contribution to conference › Conference abstract for conference › Research
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Projects
- 3 Finished
Klarlægning af dynamik og mekanismer for smitte med Salmonella fra kronisk inficerede individer
01/11/2015 → 31/10/2016
Project: Research
Mechanisms of chronic infection of food-production animals by Salmonella
01/02/2013 → 31/03/2017
Project: Research
Press / Media
RUC får 1,6 mio. kr. til forskning i salmonella fra Novo Nordisk Fonden
19/12/2019
1 item of Media coverage
Press/Media: Press / Media