Photo of Johnny T. Ottesen
  • Universitetsvej 1, 27.1

    DK-4000 Roskilde

    Denmark

1988 …2019
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Research Output 1988 2019

2019

Bridging blood cancers and inflammation: The reduced Cancitis model

Ottesen, J. T., Pedersen, R. K., Sajid, Z., Gudmand-Høyer, J., Bangsgaard, K. O., Skov, V., Kjær, L., Knudsen, T. A., Pallisgaard, N., Hasselbalch, H. & Wienecke Andersen, M., 2019, In : Journal of Theoretical Biology. 2019, 465, p. 90-108 19 p.

Research output: Contribution to journalJournal articleResearchpeer-review

File

Cardiovascular dynamics during head-up tilt assessed via a pulsatile and non-pulsatile model

Williams, N., Brady, R., Steven, G., Gremaud, P., Tran, H., Ottesen, J. T., Mehlsen, J. & Olufsen, M., 2019, (Accepted/In press) In : Journal of Mathematical Biology. 29 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Mathematical analysis of the Cancitis model and the role of inflammation in blood cancer progression

Sajid, Z., Wienecke Andersen, M. & Ottesen, J. T., 2019, In : Mathematical Biosciences and Engineering. 16, 6, p. 8268-8289 22 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
2018

Analysis and validation of a new extended method for estimating plasma free cortisol including neutrophil elastase and competition from other steroids

Gudmand-Høyer, J. & Ottesen, J. T., Jul 2018, In : The Journal of Steroid Biochemistry and Molecular Biology. 181, p. 109-124 16 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

ICP curve morphology and intracranial flow-volume changes: a simultaneous ICP and cine phase contrast MRI study in humans

Unnerbäck, M., Ottesen, J. T. & Reinstrup, P., 2018, In : Acta Neurochirurgica. 160, 2, p. 219-224 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Parameter subset selection techniques for problems in mathematical biology

Ottesen, J. T., Haargaard-Olsen, C., Smith, R. & Olufsen, M., 30 Oct 2018, In : Biological Cybernetics. p. 1-18 19 p.

Research output: Contribution to journalJournal articleResearch

Personalized mathematical model of endotoxin-induced inflammatory responses in young men and associated changes in heart rate variability

Brady, R., Frank-Ito, D., Tran, H., Janum, S., Møller, K., Brix, S., Ottesen, J. T., Mehlsen, J. & Olufsen, M., 2018, In : Mathematical Modelling of Natural Phenomena. 13, 5, 20 p., 42.

Research output: Contribution to journalJournal articleResearchpeer-review

2017

Integrated Inflammatory Stress (ITIS) model

Bangsgaard, E., Hjorth, P. G., Olufsen, M., Mehlsen, J. & Ottesen, J. T., 2017, In : Bulletin of Mathematical Biology. 79, 7, p. 1487-1509 22 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Mathematical Modelling as a Proof of Concept for MPNs as a Human Inflammation Model for Cancer Development

Andersen, M., Sajid, Z., Pedersen, R. K., Gudmand-Høyer, J., Ellervik, C., Skov, V., Kjær, L., Pallisgaard, N., Kruse, T., Thomassen, M., Troelsen, J. T., Hasselbalch, H. & Ottesen, J. T., 2017, In : P L o S One. 12, 8, e0183620.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Model-assisted assessment of aging and hypertension on cerebral blood flow velocity

Mader, G., Ottesen, J. T., Timmermann, S. & Olufsen, M., 2017, (Unpublished) In : Bulletin of Mathematical Biology. 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Modeling Predicts Kidney Function for Patients after a Kidney Transplant

Podichetty, J. T., Nielsen, M. B., Birn, H. & Ottesen, J. T., 2017, In : Journal of Pharmacokinetics and Pharmacodynamics. 44, Suppl. 1, p. S43-S44 M-075.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Modeling the differentiation of A- and C-type baroreceptor firing patterns

Sturdy, J., Ottesen, J. T. & Olufsen, M., 2017, In : Journal of Computational Neuroscience. 42, 1, p. 11-30 20 p.

Research output: Contribution to journalJournal articleResearchpeer-review

File

Patient specific modeling of the HPA axis related to clinical diagnosis of depression

Bangsgaard, E. & Ottesen, J. T., 2017, In : Mathematical Biosciences. 287, p. 24-35 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

File
2016

Characterisation of Population Pharmacokinetics and Endogenous Follicle Stimulating Hormone (FSH) Levels after Multiple Dosing of a Recombinant Human FSH, FE 999049, in Healthy Women

Rose, T. H., Röshammer, D., Erichsen, L., Grundemar, L. & Ottesen, J. T., 2016, In : Drugs in R&D. 16, 2, p. 165-172 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Global Stability in Dynamical Systems with Multiple Feedback Mechanisms

Andersen, M., Vinther, F. & Ottesen, J. T., 2016, In : Advances in Pure Mathematics. 6, 5, p. 393-407 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Population Pharmacokinetic Modelling of FE 999049, a Recombinant Human Follicle-Stimulating Hormone, in Healthy Women After Single Ascending Doses

Rose, T. H., Röshammar, D., Erichsen, L., Grundemar, L. & Ottesen, J. T., 2016, In : Drugs in R&D. 16, 2, p. 173-180 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Rate of Threading a Cellulose Chain into the Binding Tunnel of a Cellulase

Cruys-Bagger, N., Alasepp, K., Andersen, M., Ottesen, J. T., Borch, K. & Westh, P., 2016, In : The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. 120, 25, 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2015

Absorption and initial metabolism of 75Se-L-selenomethionine: a kinetic model based on dynamic scintigraphic data

Große, M. R., Søndergaard, L., Ditlevsen, S., Damgaard, M., Fuglsang, S., Ottesen, J. T. & Madsen, J. L., 28 Nov 2015, In : British Journal of Nutrition. 114, 10, p. 1718-1723

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Patient specific modelling in diagnosing depression

Ottesen, J. T., 2015, (Submitted) In : I F A C Workshop Series. 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2014

Bifurcation Analysis of an Existing Mathematical Model Reveals Novel Treatment Strategies and Suggests Potential Cure for Type 1 Diabetes

Nielsen, K. H. M., Ottesen, J. T. & Pociot, F., 1 Sep 2014, In : Mathematical Medicine and Biology (Print). 31, 3, p. 205 - 225 21 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Mathematical methods and models in system biomedicine

Pontrelli, G., Olufsen, M. & Ottesen, J. T., 2014, In : Mathematical Biosciences. 257

Research output: Contribution to journalJournal articleResearchpeer-review

Patient Specific Modeling of Head-Up Tilt

Williams, N., Wright, A., Mehlsen, J., Ottesen, J. T., Olufsen, M. & Wind-Willasen, O., 1 Dec 2014, In : Mathematical Medicine and Biology (Print). 31, 4, p. 365-391 26 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Patient-specific modeling of the neuroendocrine HPA-axis and its relation to depression: Ultradian and circadian oscillations

Gudmand-Høyer, J., Ottesen, S. T. & Ottesen, J. T., 3 Sep 2014, In : Mathematical Biosciences. 257, p. 23-32 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Structural correlation method for model reduction and practical estimation of patient specific parameters illustrated on heart rate regulation

Ottesen, J. T., Mehlsen, J. & Olufsen, M., 1 Nov 2014, In : Mathematical Biosciences. 257, p. 50 - 59 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2013

A practical approach to parameter estimation applied to model predicting heart rate regulation

Olufsen, M. & Ottesen, J. T., Jul 2013, In : Journal of Mathematical Biology. 67, 1, p. 39-68 29 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Development of patient specific cardiovascular models predicting dynamics in response to orthostatic stress challenges

Ottesen, J. T., 2013, Mathematical Modeling and Validation in Physiology: Applications to the cardiovascular and respiratory systems. Batzel, J., Bachar, M. & Kappel, F. (eds.). Hedelberg: Springer, p. 177-214 37 p. (Lecture Notes in Mathematics, Vol. 2064).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Etiology and Diagnosis of Major Depression - A Novel Quantitative Approach

Ottesen, J. T., May 2013, In : Open Journal of Endocrine and Metabolic Diseases. 3, 2, p. 120-127 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Mathematical modelling of the Hypothalamic-Pituritary-Adrenal glad (HPA)-axis; Including Hippocampal mechanicsms

Ottesen, J. T., Vinther, F. & Andersen, M., Nov 2013, In : Mathematical Biosciences. 246, 1, p. 122-138 16 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Modeling the Afferent Dynamics of the Baroreflex Control System

Ottesen, J. T., Mahdi, A., Sturdy, J. & Olufsen, M., Dec 2013, In : P L o S Computational Biology (Online). 9, 12, p. 1-18 18 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
2012

Global sensitivity and identifiability analysis applied to a model predicting baroreflex regulation during head-up tilt

olsen, C., Mehlsen, J., Ottesen, J. T., Tran, H. & Olufsen, M., 2012, Proceeding of The 1st international workshop on innovative simulation for healthcare, I-WISH. p. 81-86

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Qualitative features of a new baroreceptor model

Mahdi, A., Ottesen, J. T. & Olufsen, M., 2012, Proceeding of the 1st international workshop on innovative simulation for healthcare. p. 75-80

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Structural correlation method for practical estimation of patient specific parameters in heart rate regulation

Ottesen, J. T. & Olufsen, M., 2012, Proceedings of the 1st international workshop on innovative simulation for healthcare. p. 136-143

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

2011

Developement of patient specific cardiovascular models predicting dynamics in response to orthostatic challanges

Ottesen, J. T., Novak, V. & Olufsen, M., 2011, proceedings in the Springer Lecture Notes in Mathematics (LNM) series on Biosciences. Springer, 45 p.

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

Functionality of the baroreceptor nerves in heart rate regulation

Ottesen, J. T. & Olufsen, M., Feb 2011, In : Computer Methods and Programs in Biomedicine. 101, 2, p. 208-219

Research output: Contribution to journalJournal articleResearchpeer-review

The impact of gravity during head-up tilt

Ottesen, J. T., Olufsen, M., Smith, B. & Mehlsen, J., 2011. 3 p.

Research output: Contribution to conferencePaperResearchpeer-review

The Mathematical Microscope - Making the inaccessible accessible

Ottesen, J. T., 2011, BetaSys: Systems biology of regulated exocytosis in pancreatic β-cells. Booß-Bavnbek, B., Klösgen, B., Larsen, J., Pociot, F. & Renström, E. (eds.). Springer, p. 97-118 20 p. (Systems Biology, Vol. 2).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

The Minimal Model of the Hypothalamic-Pituitary-Adrenal Axis

Vinther, F., Andersen, M. & Ottesen, J. T., 2011, In : Journal of Mathematical Biology. 63, 4, p. 663-690 27 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2010

Bio-Matematik ved Roskilde Universitet

Ottesen, J. T., 2010, In : Medicinsk Teknologi og Informatik. 7, p. 4-8 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2009

Molecular Dynamics Simulation of Valveless Pumping in a Closed Nanofluidic Tube System: A Study of the Local Streaming Velocity

Hansen, J. S. & Ottesen, J. T., 2009, In : Journal of Computational and Theoretical Nanoscience. 6, 3, p. 593-598 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Novel Characteristics of Valveless Pumping

Timmermann, S. & Ottesen, J. T., 2009, In : Physics of Fluids. 21, 5, 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

On the track of syncope induced by orthostatic stress - feedback mechanisms regulating the cardiovascular system

Ottesen, J. T., 2009, In : Elsevier IFAC Publications / IFAC Proceedings series. p. 187-191 5 p.

Research output: Contribution to journalConference articleResearchpeer-review

2008

Matematisk modellering og kardiovaskulær fysiologi

Ottesen, J. T., 2008, In : Matilde. 34, p. 4-11 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Modeling heart rate regulation - Part I: Sit-to-stand versus Head-up tilt

Olufsen, M. S., Alston, A. V., Tran, H. T., Ottesen, J. T. & Novak, V., 2008, In : Cardiovascular Engineering - an International Journal. 8, 2, p. 73-87 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2006

BASE - et grundkursus i matematisk modellering. 1. del og 2. del.

Kjeldsen, T. H., Blomhøj, M. & Ottesen, J. T., 2006, Roskilde Universitetscenter: Roskilde Universitet.

Research output: Book/ReportCompendium/lecture notesEducation

BASE - et grundkursus i matematisk modellering. Problemstillinger til miniprojekter

Kjeldsen, T. H., Morten, M. & Ottesen, J. T., 2006, Roskilde: Roskilde Universitet.

Research output: Book/ReportCompendium/lecture notesEducation

Cardiovascular modelling at IMFUFA

Larsen, J., Andreasen, V., Olufsen, M. S., Ottesen, J. T. & Larsen, H., 2006, The way through science and philosophy: Essays in honour of Stig Andur Pedersen. Andersen, H. B., Christiansen, F. V., Jørgensen, K. F. & Hendricks, V. F. (eds.). London: College Publications, p. 87-96 10 p.

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

Modeling baroreflex regulation of heart rate during orthostatic stress

Olufsen, M., Tran, H. T., Ottesen, J. T., Lipsitz, L. A. & Novak, V., 2006, In : American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 291, 5, p. 1355-1368 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Molecular dynamics simulations of oscillatory flows in microfluidic channels

Hansen, J. S. & Ottesen, J. T., 2006, In : Microfluidics and Nanofluidics. 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

The Donders model of the circulation in normo- and pathophysiology

Noordergraaf, G. J., Ottesen, J. T., Kortsmit, W. J. P. M., Schilders, W. H. A., Scheffer, G. J. & Noordergraaf, A., 2006, In : Cardiovascular Engineering - an International Journal. 6, 2, p. 51-70 19 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2005

Alumped parameter model predicting cerebral autoregulation and autonomic regulation in young people

Olufsen, M. S., Tran, H. T., Ottesen, J. T., Ellwein, L., Lipsitz, L. A. & Novak, V., 2005, SIAM Conference on Control and its Application. Society for Industrial and Applied Mathematics, 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearch