Treatment of Parkinson’s Disease by stem cells

Evelina Martinenaite, Juliette Tavenier, Elayne Elvira Lorenzen & Ursula Izabel Waltemath

Studenteropgave: Semesterprojekt

Abstrakt

Parkinson’s disease (PD) represents in today’s society one of the most common neurodegenerative diseases. An important progress has been made in recent years, in the development of therapeutic treatments for this disease. However, no cure has been found yet. When discovered, the treatment of PD by the use of L-dopa as a therapy was anticipated to be a sufficient one. But with time, a loss of effectiveness has been noticed in patients after five to fifteen years of this treatment. Therefore we searched for a way of treating Parkinson’s disease that would give rise to no or few side effects to the patients, so we decided to research stem cell therapy. This paper contains studies of the function of a normal brain in order to then have a better insight on the processes occurring in the brain of the patients suffering from PD. For this, we used scientific journals, reviews and books. We also looked into theoretical knowledge of stem cells, the different types of stem cells that exist and how each of them could be used to treat Parkinson’s disease. Based on the information from various research articles, we made the following conclusions: embryonic stem cells (ESCs) and somatic cells induced into pluripotent stem cells are the most efficient. However, ESCs have a high risk of tumor formation and rejection of the graft from the host organism. While using induced pluripotent stem (iPS) cells, there is an extremely low risk of graft rejection since the cells are taken from the patient; nonetheless, the risk of tumor formation remains present.

UddannelserBasis - International Naturvidenskabelig Bacheloruddannelse, (Bachelor uddannelse) Basis
SprogEngelsk
Udgivelsesdato14 jan. 2010

Emneord

  • stem cells
  • Parkinson's disease
  • stem cell therapy
  • brain