The cellular enlargement with Resveratrol in connection with SIRT1 and mTOR, on colon cancer cells

Andreas Wolff, Alexandre Vieira & Charles Friday

Studenteropgave: Semesterprojekt

Abstrakt

Resveratrol is a natural occurring molecule, which has shown promising effects in animal models. Even though a lot of studies have been done on resveratrol, information regarding which genes are activated by resveratrol, which causes change to the cells size, is still missing. The aim of our study is to examine the cellular effects of resveratrol on growth factor of cell size with the modulating role, tempering with the mTOR cascade and SIRT1 enzymes. Our results have indicated that cellular enlargement is tightly connected SIRT1. This was found when the cell was treated with resveratrol and while either SIRT1 or mTOR was inhibited. Our experiments suggest that resveratrol is increasing the cell size via activation of the silent regulator gene (SIRT1).

UddannelserBasis - International Naturvidenskabelig Bacheloruddannelse, (Bachelor uddannelse) Basis
SprogEngelsk
Udgivelsesdato22 jun. 2012
VejledereOle Vang

Emneord

  • Resveratrol
  • mTOR
  • SIRT1