Serotonin & Depression

Ida Axholm, Nina Haxgart, Kasper Ranum & Astrid Helmer Svendsen

Studenteropgave: Semesterprojekt


350.000.000 people worldwide have a depression and 150.000 Danes are affected every year. Depresion is defined by WHO from it’s syptoms. The diagnose is given from a point system for the patient’s symptoms, for instance HAM-D scale and MADRS scale Serotonin in the brain is synthesized from L-tryptophan in the presynaptic parts of the neuron and is released into the synapse as a transmitter drug. According to the serotonin theory, the concentration of serotonin in the brain is low in depression. SSRIs inhibit the reuptake more selectively than other antidepressants. 75% of their effect can be duplicated by inert placebo and 25% by active placebo. FDA has approved SSRIs in the US, but their assessment of the studies is selective and the approval should be reassessed. Tryptophan affects the serotonin synthesis and tryptophan depletion cannot incite a depression. Studies of treatment of depression with tryptophan had contradictory results. SSREs works just as well as SSRIs, have fewer side effects and increases the neuroplasticity through depletion of the serotonin concentration. The cause of depression is more complex than the serotonin theory can account for, and it can be falsified. The SSRIs are not more effective than active placebo. Therefore there is no foundation for treating depression with SSRIs.

UddannelserBasis - Naturvidenskabelig Bacheloruddannelse, (Bachelor uddannelse) Basis
Udgivelsesdato15 jan. 2014
VejledereMorten Brandrup


  • Serotoninteorien
  • Serotonin
  • Depression